Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19
As the COVID-19 pandemic enters its fifth year, research tools to study the SARS-CoV-2 (CoV-2) virus are critical, and many researchers have turned to another beta coronavirus: HCoV-OC43 (OC43). OC43 is a ubiquitous pathogen that now causes a common cold, but its emergence in 1890 closely coincided...
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Elsevier
2024-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624001832 |
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| author | Catherine LaCourse |
| author_facet | Catherine LaCourse |
| author_sort | Catherine LaCourse |
| collection | DOAJ |
| description | As the COVID-19 pandemic enters its fifth year, research tools to study the SARS-CoV-2 (CoV-2) virus are critical, and many researchers have turned to another beta coronavirus: HCoV-OC43 (OC43). OC43 is a ubiquitous pathogen that now causes a common cold, but its emergence in 1890 closely coincided with and likely produced the catastrophic Russian Flu pandemic. Beyond their historical parallels, OC43 and CoV-2 share similar genetics and disease sequelae. Both viruses induce respiratory symptoms. Additionally, OC43 infection can result in acute neurological dysfunction in children, and exposure to OC43 has been linked to long-term neurological disorders in adults. Similarly, CoV-2 can produce acute neuropathology and the phenomenon of prolonged symptoms known as Long-COVID that typically impacts the brain. Mouse models have been developed to study the pathogenesis of both OC43 and CoV-2, thereby facilitating research on the neurological sequelae associated with either infection. These models have been further utilized to test therapeutic interventions against both viruses, as researchers seek to establish the potential for using OC43 as a proxy for CoV-2. Further, because mouse models of the two betacoronaviruses exhibit neurological sequelae, using OC43 likely could provide insight into the impact of COVID-19 on the brain. OC43 requires a lower biosafety level than CoV-2, which makes it accessible to more researchers resulting in expeditious scientific progress in the ongoing COVID-19 pandemic. |
| format | Article |
| id | doaj-art-afb1ea9236d74d7f885ab2b852f682a5 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-afb1ea9236d74d7f885ab2b852f682a52024-12-02T05:06:46ZengElsevierBrain, Behavior, & Immunity - Health2666-35462024-12-0142100905Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19Catherine LaCourse0Stanley Division of Developmental Neurovirology, Department of Pediatrics, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.As the COVID-19 pandemic enters its fifth year, research tools to study the SARS-CoV-2 (CoV-2) virus are critical, and many researchers have turned to another beta coronavirus: HCoV-OC43 (OC43). OC43 is a ubiquitous pathogen that now causes a common cold, but its emergence in 1890 closely coincided with and likely produced the catastrophic Russian Flu pandemic. Beyond their historical parallels, OC43 and CoV-2 share similar genetics and disease sequelae. Both viruses induce respiratory symptoms. Additionally, OC43 infection can result in acute neurological dysfunction in children, and exposure to OC43 has been linked to long-term neurological disorders in adults. Similarly, CoV-2 can produce acute neuropathology and the phenomenon of prolonged symptoms known as Long-COVID that typically impacts the brain. Mouse models have been developed to study the pathogenesis of both OC43 and CoV-2, thereby facilitating research on the neurological sequelae associated with either infection. These models have been further utilized to test therapeutic interventions against both viruses, as researchers seek to establish the potential for using OC43 as a proxy for CoV-2. Further, because mouse models of the two betacoronaviruses exhibit neurological sequelae, using OC43 likely could provide insight into the impact of COVID-19 on the brain. OC43 requires a lower biosafety level than CoV-2, which makes it accessible to more researchers resulting in expeditious scientific progress in the ongoing COVID-19 pandemic.http://www.sciencedirect.com/science/article/pii/S2666354624001832 |
| spellingShingle | Catherine LaCourse Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 Brain, Behavior, & Immunity - Health |
| title | Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 |
| title_full | Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 |
| title_fullStr | Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 |
| title_full_unstemmed | Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 |
| title_short | Utilizing HCoV-OC43 to better understand the neurological impact of COVID-19 |
| title_sort | utilizing hcov oc43 to better understand the neurological impact of covid 19 |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624001832 |
| work_keys_str_mv | AT catherinelacourse utilizinghcovoc43tobetterunderstandtheneurologicalimpactofcovid19 |