Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness

Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness

Abstract Background Breast cancer is the leading cause of cancer-related mortality in women. Deregulation of miRNAs is frequently observed in breast cancer and affects tumor biology. A pre-miRNA, such as pre-miR-1307, gives rise to several mature miRNA molecules with distinct functions. However, the...

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Main Authors: Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Breast cancer
Angiogenesis
miRNAs
IsomiRs
miR-1307
miRNA arm switch
Online Access:https://doi.org/10.1186/s12915-025-02133-x
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