Research progress in drug repurposing in the treatment of breast cancer
Breast cancer has become one of the most prevalent cancers among women worldwide, posing a significant burden on their health. Current standard therapies are often expensive and associated with the risk of drug resistance. Drug repurposing has gained increasing attention as a cost-effective and time...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2024-11-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1454.shtml |
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| _version_ | 1846116410819870720 |
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| author | TAN Chen XU Zhangrun XUE Yang CHEN Jiayu YAO Lijun |
| author_facet | TAN Chen XU Zhangrun XUE Yang CHEN Jiayu YAO Lijun |
| author_sort | TAN Chen |
| collection | DOAJ |
| description | Breast cancer has become one of the most prevalent cancers among women worldwide, posing a significant burden on their health. Current standard therapies are often expensive and associated with the risk of drug resistance. Drug repurposing has gained increasing attention as a cost-effective and time-saving strategy in pharmaceutical research. Many drugs already in clinical use or undergoing clinical trials can be repurposed for the treatment of new clinical indications. Based on a comprehensive understanding of the mechanisms of action of these drugs and the pathophysiological processes of breast cancer, researchers can better identify drugs with potential anti-breast cancer properties and translate them into clinical practice. This paper provides a review of the current research on repurposing existing drugs for breast cancer treatment, summarizes the mechanisms of action of these drugs, and discusses the challenges associated with the strategy of drug repurposing. |
| format | Article |
| id | doaj-art-af63d73ff35b4075a959382d54af2549 |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-af63d73ff35b4075a959382d54af25492024-12-19T02:09:02ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152024-11-0144111454145910.3969/j.issn.1674-8115.2024.11.0131674-8115（2024）11-1454-06Research progress in drug repurposing in the treatment of breast cancerTAN Chen0XU Zhangrun1XUE Yang2CHEN Jiayu3YAO Lijun4Department of Orthopedics, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200030, ChinaLaboratory of Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaDepartment of Clinical Laboratory, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200030, ChinaDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200011, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200030, ChinaBreast cancer has become one of the most prevalent cancers among women worldwide, posing a significant burden on their health. Current standard therapies are often expensive and associated with the risk of drug resistance. Drug repurposing has gained increasing attention as a cost-effective and time-saving strategy in pharmaceutical research. Many drugs already in clinical use or undergoing clinical trials can be repurposed for the treatment of new clinical indications. Based on a comprehensive understanding of the mechanisms of action of these drugs and the pathophysiological processes of breast cancer, researchers can better identify drugs with potential anti-breast cancer properties and translate them into clinical practice. This paper provides a review of the current research on repurposing existing drugs for breast cancer treatment, summarizes the mechanisms of action of these drugs, and discusses the challenges associated with the strategy of drug repurposing.https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1454.shtmldrug repurposingbreast cancerchemotherapyanti-tumor |
| spellingShingle | TAN Chen XU Zhangrun XUE Yang CHEN Jiayu YAO Lijun Research progress in drug repurposing in the treatment of breast cancer Shanghai Jiaotong Daxue xuebao. Yixue ban drug repurposing breast cancer chemotherapy anti-tumor |
| title | Research progress in drug repurposing in the treatment of breast cancer |
| title_full | Research progress in drug repurposing in the treatment of breast cancer |
| title_fullStr | Research progress in drug repurposing in the treatment of breast cancer |
| title_full_unstemmed | Research progress in drug repurposing in the treatment of breast cancer |
| title_short | Research progress in drug repurposing in the treatment of breast cancer |
| title_sort | research progress in drug repurposing in the treatment of breast cancer |
| topic | drug repurposing breast cancer chemotherapy anti-tumor |
| url | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1454.shtml |
| work_keys_str_mv | AT tanchen researchprogressindrugrepurposinginthetreatmentofbreastcancer AT xuzhangrun researchprogressindrugrepurposinginthetreatmentofbreastcancer AT xueyang researchprogressindrugrepurposinginthetreatmentofbreastcancer AT chenjiayu researchprogressindrugrepurposinginthetreatmentofbreastcancer AT yaolijun researchprogressindrugrepurposinginthetreatmentofbreastcancer |