Irradiation of prostate cancer alters circulating small extracellular vesicle functions

Irradiation of prostate cancer alters circulating small extracellular vesicle functions

Abstract It is known that β1 integrins and a downstream signaling molecule c-Src are upregulated in prostate cancer (PrCa) tissues, are co-expressed in circulating small extracellular vesicles (sEVs) and contribute to cancer progression. Here, we demonstrate that sEVs from PrCa patients show robust...

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Bibliographic Details
Main Authors: Aejaz Sayeed, Vaughn Garcia, Cecilia E. Verrillo, Rachel M. DeRita, Md Niamat Hossain, Shiv Ram Krishn, Samuel Sey, Christopher D. Shields, Adrian D. Altieri, Qin Liu, Khalid Sossey-Alaoui, William K. Kelly, Lucia R. Languino
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
β1 integrin subunit
c-Src
Small extracellular vesicles
Prostate cancer
TRAMP
Irradiation
Online Access:https://doi.org/10.1038/s41598-025-03329-5
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