Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease

Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease

ABSTRACT Acute rheumatic fever (ARF) is an autoimmune disease triggered by antibodies and T cells targeting the group A Streptococcus (GAS, Strep A) bacterium, often leading to rheumatic heart disease (RHD) and Sydenham’s chorea. Long-term monthly penicillin injections are recognized as a cornerston...

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Bibliographic Details
Main Authors: Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan, Michael F. Good, Manisha Pandey, Ailin Lepletier
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
acute rheumatic fever
rheumatic heart disease
group A streptococcus
low-dose interleukin-2
immunotherapy
autoimmune diseases
Online Access:https://journals.asm.org/doi/10.1128/mbio.03823-24
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