Apoptosis in bovine ocular squamouse cell carcinomas
<b>Aim: </b>Cell death, especially apoptosis, is one of the most studied topics regarding cells. Understanding the mechanism of apoptosis in diseases will help understand the pathogenesis of diseases, as well as the treatment. This study aims to grade the Bovine ocular squamous cell carc...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2022-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1395 |
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| Summary: | <b>Aim: </b>Cell death, especially apoptosis, is one of the most studied topics
regarding cells. Understanding the mechanism of apoptosis in
diseases will help understand the pathogenesis of diseases, as well
as the treatment. This study aims to grade the Bovine ocular squamous
cell carcinoma (BOSCC) and to evaluate apoptosis in tumors
with different anaplastic features.<p>
<b>Materials and Methods:</b> A total of 30 formalin-fixed tumor tissues
consisting of 10 poorly-differentiated, 10 moderately-differentiated,
and 10 well-differentiated tissues were used to examine apoptosis in
BOSCCs. Hematoxylin & eosin (HE) was performed for histopathological
examination and TUNEL staining was performed for detection
of apoptosis in all BOSCCs.<p>
<b>Results:</b> It was determined that apoptosis decreased as the malignancy
increased in BOSCCs (p<0.001). Although all the tumors
examined were malignant, apoptosis, i.e. controlled cell death, was
found to be severe in well-differentiated type and mild in moderate
and poorly-differentiated types.<p>
<b>Conclusion:</b> It was concluded that this case observed in bovines
should be considered in studies on the pathogenesis of cancer and
treatment. |
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| ISSN: | 1309-6958 2146-1953 |