A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

Abstract The SARS-CoV-2 nucleocapsid protein is indispensable for viral RNA genome processing. Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions, high-resolution structures with viral RNA are still lacking. Available hybrid structures of the NTD with ssRNA and ds...

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Main Authors: Karthikeyan Dhamotharan, Sophie M. Korn, Anna Wacker, Matthias A. Becker, Sebastian Günther, Harald Schwalbe, Andreas Schlundt
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55024-0
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