Alterations in GSH/GSSG and CyS/CySS redox status in small cell lung cancer patients undergoing chemotherapy

Alterations in GSH/GSSG and CyS/CySS redox status in small cell lung cancer patients undergoing chemotherapy

Abstract Background In small cell lung cancer (SCLC), oxidative stress disrupts redox balance and contributes to tumor progression and treatment resistance through DNA damage, inflammation, and tumorigenesis. Thiol compounds such as glutathione (GSH) and cysteine (CyS) together with their oxidized f...

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Bibliographic Details
Main Authors: Azra Guzonjić, Milkica Crevar, Ivana Simić, Natalija Samardzić, Vesna Ćeriman Krstić, Jelena Kotur Stevuljević, Dragana Jovanović
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Oxidative stress
Lung cancer
Redox imbalance
Prognostic biomarkers
Online Access:https://doi.org/10.1007/s12672-025-03251-2
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