Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer

Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer

Abstract Phospholipase D6 (PLD6) is a critical enzyme involved in mitochondrial fusion with a key role in spermatogenesis. However, the role of PLD6 in cancer remains unknown. Notably, Wnt signaling, energy metabolism and mitochondrial function show complex interactions in colorectal cancer (CRC) pr...

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Bibliographic Details
Main Authors: Hyun Ji Lee, Seong Hun Lim, Hyesung Lee, Jung Min Han, Do Sik Min
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01446-9
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