Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial
Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS). Materials and Methods: This double-blind randomized clinical trial was conducted on 50 patients with DS types I and II assigned to two grou...
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Tehran University of Medical Sciences
2024-12-01
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| Series: | Frontiers in Dentistry |
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| Online Access: | https://fid.tums.ac.ir/index.php/fid/article/view/4526 |
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| author | Fahimeh Pakravan Afsaneh Yegdaneh Somayeh Taymouri Shiva Rahimi Negin Ghahremani |
| author_facet | Fahimeh Pakravan Afsaneh Yegdaneh Somayeh Taymouri Shiva Rahimi Negin Ghahremani |
| author_sort | Fahimeh Pakravan |
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Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS).
Materials and Methods: This double-blind randomized clinical trial was conducted on 50 patients with DS types I and II assigned to two groups (N=25). In the first group, G. lucidum extract was administered in the form of 5% gel while 1% clotrimazole gel was prescribed for the second group. Pain intensity according to the visual analog scale (VAS), and the percentage of DS recovery based on the Budtz-Jorgenson index were evaluated and recorded after 7 and 14 days. Data were analyzed using the Chi-square test, independent samples t-test, repeated measures ANOVA, and logistic regression (alpha=0.05).
Results: The percentage of complete recovery on day 7 in the G. lucidum group (28%) was higher than that in the clotrimazole group (16%) but not significantly (P=0.592). Not wearing dentures overnight significantly increased the odds of recovery by 6.56 times, while the odds of recovery decreased by 0.03 times in DS type II, as compared to DS type I (P= 0.009).Conclusion: No significant difference existed between the antifungal efficacy of G. lucidum and clotrimazole for clinical treatment of DS. Thus, Ganoderma may be regarded as an alternative treatment, especially in patients’ resistant to azoles. Nonetheless, further clinical studies are required to shed more light on this topic.
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| format | Article |
| id | doaj-art-aeccd6bb1f2c4726bb93c06168a81582 |
| institution | Kabale University |
| issn | 2676-296X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Dentistry |
| spelling | doaj-art-aeccd6bb1f2c4726bb93c06168a815822025-01-06T08:37:51ZengTehran University of Medical SciencesFrontiers in Dentistry2676-296X2024-12-012110.18502/fid.v21i45.17178Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical TrialFahimeh Pakravan0Afsaneh Yegdaneh1Somayeh Taymouri2Shiva Rahimi3Negin Ghahremani4Department of Oral Medicine, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment. of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Novel Drug Delivery System Research Center, Isfahan University of Medical Sciences, Isfahan, IranStudent Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranStudent Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS). Materials and Methods: This double-blind randomized clinical trial was conducted on 50 patients with DS types I and II assigned to two groups (N=25). In the first group, G. lucidum extract was administered in the form of 5% gel while 1% clotrimazole gel was prescribed for the second group. Pain intensity according to the visual analog scale (VAS), and the percentage of DS recovery based on the Budtz-Jorgenson index were evaluated and recorded after 7 and 14 days. Data were analyzed using the Chi-square test, independent samples t-test, repeated measures ANOVA, and logistic regression (alpha=0.05). Results: The percentage of complete recovery on day 7 in the G. lucidum group (28%) was higher than that in the clotrimazole group (16%) but not significantly (P=0.592). Not wearing dentures overnight significantly increased the odds of recovery by 6.56 times, while the odds of recovery decreased by 0.03 times in DS type II, as compared to DS type I (P= 0.009).Conclusion: No significant difference existed between the antifungal efficacy of G. lucidum and clotrimazole for clinical treatment of DS. Thus, Ganoderma may be regarded as an alternative treatment, especially in patients’ resistant to azoles. Nonetheless, further clinical studies are required to shed more light on this topic. https://fid.tums.ac.ir/index.php/fid/article/view/4526ReishiClotrimazoleAntifungal Agents |
| spellingShingle | Fahimeh Pakravan Afsaneh Yegdaneh Somayeh Taymouri Shiva Rahimi Negin Ghahremani Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial Frontiers in Dentistry Reishi Clotrimazole Antifungal Agents |
| title | Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_full | Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_fullStr | Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_full_unstemmed | Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_short | Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_sort | antifungal efficacy of ganoderma lucidum and clotrimazole for treatment of denture stomatitis a randomized clinical trial |
| topic | Reishi Clotrimazole Antifungal Agents |
| url | https://fid.tums.ac.ir/index.php/fid/article/view/4526 |
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