Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
To investigate the correlation between blood stasis syndrome and arteriopathy in immunoglobulin A nephropathy (IgAN). Wall thickness/outer vessel diameter, intimal thickness/outer vessel diameter, and medial thickness/outer vessel diameter were measured using ImageJ software. Vascular endothelial-de...
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De Gruyter
2024-12-01
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| Online Access: | https://doi.org/10.1515/med-2024-1042 |
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| author | Wang Ruiqi Tian Yun |
| author_facet | Wang Ruiqi Tian Yun |
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| description | To investigate the correlation between blood stasis syndrome and arteriopathy in immunoglobulin A nephropathy (IgAN). Wall thickness/outer vessel diameter, intimal thickness/outer vessel diameter, and medial thickness/outer vessel diameter were measured using ImageJ software. Vascular endothelial-derived growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK) 1/2, and nuclear factor kappa B (NF-κB) were detected by immunohistochemical staining. Twenty-four-hour urine protein quantification, serum creatinine, urea nitrogen, and uric acid were collected. Blood stasis syndrome and vessel scores were calculated based on Katafuchi’s grade. Intimal thickness/outer vessel diameter (0.2725 ± 0.0932 μm), medial thickness/outer vessel diameter (0.2747 ± 0.1139 μm), and wall thickness/outer vessel diameter (0.6136 ± 0.1120 μm) were the largest in IgAN with arteriopathy group. VEGF (0.35 ± 0.90), MMP-9 (0.38 ± 0.12), PCNA (0.43 ± 0.12), ERK1/2 (0.31 ± 0.11), and NF-κB (0.37 ± 0.14) were the highest in IgAN with arteriopathy group. Intimal thickening of IgAN was moderately positively correlated with VEGF, MMP-9, PCNA, ERK1/2, and NF-κB (0.5 < r < 0.8). Medial thickening of IgAN was moderately positively correlated with PCNA and NF-κB (0.5 < r < 0.8). Wall thickening of IgAN was lowly positively correlated with VEGF and MMP-9 (0.3 < r < 0.5). Blood stasis syndrome score was associated with vessel score in IgAN with arteriopathy (P < 0.05). Blood stasis syndrome score can assess the degree of pathological changes. |
| format | Article |
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| institution | Kabale University |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-aec9c1f6314c42d69d06bcd318804f132024-12-10T07:31:39ZengDe GruyterOpen Medicine2391-54632024-12-011912785910.1515/med-2024-1042Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort studyWang Ruiqi0Tian Yun1Department of Traditional Chinese Medicine, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an, 710003, ChinaDepartment of Nephrology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 4, Xihuamen, Xi’an, Shaanxi, 710003, ChinaTo investigate the correlation between blood stasis syndrome and arteriopathy in immunoglobulin A nephropathy (IgAN). Wall thickness/outer vessel diameter, intimal thickness/outer vessel diameter, and medial thickness/outer vessel diameter were measured using ImageJ software. Vascular endothelial-derived growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK) 1/2, and nuclear factor kappa B (NF-κB) were detected by immunohistochemical staining. Twenty-four-hour urine protein quantification, serum creatinine, urea nitrogen, and uric acid were collected. Blood stasis syndrome and vessel scores were calculated based on Katafuchi’s grade. Intimal thickness/outer vessel diameter (0.2725 ± 0.0932 μm), medial thickness/outer vessel diameter (0.2747 ± 0.1139 μm), and wall thickness/outer vessel diameter (0.6136 ± 0.1120 μm) were the largest in IgAN with arteriopathy group. VEGF (0.35 ± 0.90), MMP-9 (0.38 ± 0.12), PCNA (0.43 ± 0.12), ERK1/2 (0.31 ± 0.11), and NF-κB (0.37 ± 0.14) were the highest in IgAN with arteriopathy group. Intimal thickening of IgAN was moderately positively correlated with VEGF, MMP-9, PCNA, ERK1/2, and NF-κB (0.5 < r < 0.8). Medial thickening of IgAN was moderately positively correlated with PCNA and NF-κB (0.5 < r < 0.8). Wall thickening of IgAN was lowly positively correlated with VEGF and MMP-9 (0.3 < r < 0.5). Blood stasis syndrome score was associated with vessel score in IgAN with arteriopathy (P < 0.05). Blood stasis syndrome score can assess the degree of pathological changes.https://doi.org/10.1515/med-2024-1042iganarteriopathycorrelationblood stasis syndrome |
| spellingShingle | Wang Ruiqi Tian Yun Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study Open Medicine igan arteriopathy correlation blood stasis syndrome |
| title | Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study |
| title_full | Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study |
| title_fullStr | Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study |
| title_full_unstemmed | Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study |
| title_short | Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study |
| title_sort | correlation between the mechanism of arteriopathy in iga nephropathy and blood stasis syndrome a cohort study |
| topic | igan arteriopathy correlation blood stasis syndrome |
| url | https://doi.org/10.1515/med-2024-1042 |
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