Protocol for generating human assembloids to investigate thalamocortical and corticothalamic synaptic transmission and plasticity

Protocol for generating human assembloids to investigate thalamocortical and corticothalamic synaptic transmission and plasticity

Summary: Human induced pluripotent stem cells (hiPSCs) can be used to generate assembloids that recreate thalamocortical circuitry displaying short-term and long-term synaptic plasticity. Here, we describe a protocol for differentiating hiPSCs into thalamic and cortical organoids and then fusing the...

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Bibliographic Details
Main Authors: Anjana Nityanandam, Mary H. Patton, Ildar T. Bayazitov, Kyle D. Newman, Kristen T. Thomas, Stanislav S. Zakharenko
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:STAR Protocols
Subjects:
Neuroscience
Stem Cells
Organoids
Online Access:http://www.sciencedirect.com/science/article/pii/S266616672500036X
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