Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia
Objective To evaluate the effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia, aiming to determine the optimal lidocaine dose. Methods Using prospective, single-center, randomized controlled clinical trial me...
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The Editorial Department of Chinese Journal of Clinical Research
2024-12-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241208 |
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| author | KANG Cuiyao KANG Cuibi OU Xiaojing XIE Danru LI Feifei ZHANG Yiwen |
| author_facet | KANG Cuiyao KANG Cuibi OU Xiaojing XIE Danru LI Feifei ZHANG Yiwen |
| author_sort | KANG Cuiyao |
| collection | DOAJ |
| description | Objective To evaluate the effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia, aiming to determine the optimal lidocaine dose. Methods Using prospective, single-center, randomized controlled clinical trial methods, a total of 135 patients who underwent bronchoscopy in Shunde Hospital of Southern Medical University from September 2023 to June 2024 were selected, and they were randomly divided into group C (normal saline), group L1.0 (1.0 mg/kg lidocaine), and group L1.5 (1.5 mg/kg lidocaine), with 45 cases in each group. All patients received general anesthesia with laryngeal mask. After induction, lidocaine or saline was administered intravenously. The incidence and severity of cough within 30 minutes after removal of the laryngeal mask were recorded and analyzed, along with adverse events. Cough severity was categorized as mild (single episode), moderate (multiple episodes lasting over 5 s but not continuous), and severe (continuous coughing lasting over 5 s). Results There was a statistically significant difference in the incidence of cough during the recovery period after bronchoscopy among the three groups: 42.2% in group C, 22.2% in group L1.0, and 8.9% in group L1.5 (χ2=13.72, P＜0.01), and after Bonferroni correction, that in group L1.5 was significantly lower than that in group C (χ2=13.14, P＜0.01). The incidence of severe cough was 17.8%, 4.4% and 2.3% respectively, and the difference among the three groups was statistically significant (χ2=8.51, P＜0.05). Compared with group C, the incidence of postoperative nausea, vomiting and sore throat significantly reduced in group L1.0 and group L1.5 (P＜0.017). Conclusion Intravenous injection of 1.5 mg/kg lidocaine can effectively decrease the incidence of cough during the recovery period after bronchoscopy under general anesthesia, and also can significantly reduce the occurrences of nausea, vomiting and sore throat.
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| format | Article |
| id | doaj-art-aebc4d588d9c4b3a9bda4d8673913d7a |
| institution | Kabale University |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-aebc4d588d9c4b3a9bda4d8673913d7a2024-12-30T06:55:39ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822024-12-0137121854 185910.13429/j.cnki.cjcr.2024.12.008Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesiaKANG Cuiyao0KANG Cuibi1OU Xiaojing2XIE Danru3LI Feifei4ZHANG Yiwen5Department of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaDepartment of Emergency, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaDepartment of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaDepartment of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaDepartment of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaDepartment of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, Guangdong 528300, ChinaObjective To evaluate the effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia, aiming to determine the optimal lidocaine dose. Methods Using prospective, single-center, randomized controlled clinical trial methods, a total of 135 patients who underwent bronchoscopy in Shunde Hospital of Southern Medical University from September 2023 to June 2024 were selected, and they were randomly divided into group C (normal saline), group L1.0 (1.0 mg/kg lidocaine), and group L1.5 (1.5 mg/kg lidocaine), with 45 cases in each group. All patients received general anesthesia with laryngeal mask. After induction, lidocaine or saline was administered intravenously. The incidence and severity of cough within 30 minutes after removal of the laryngeal mask were recorded and analyzed, along with adverse events. Cough severity was categorized as mild (single episode), moderate (multiple episodes lasting over 5 s but not continuous), and severe (continuous coughing lasting over 5 s). Results There was a statistically significant difference in the incidence of cough during the recovery period after bronchoscopy among the three groups: 42.2% in group C, 22.2% in group L1.0, and 8.9% in group L1.5 (χ2=13.72, P＜0.01), and after Bonferroni correction, that in group L1.5 was significantly lower than that in group C (χ2=13.14, P＜0.01). The incidence of severe cough was 17.8%, 4.4% and 2.3% respectively, and the difference among the three groups was statistically significant (χ2=8.51, P＜0.05). Compared with group C, the incidence of postoperative nausea, vomiting and sore throat significantly reduced in group L1.0 and group L1.5 (P＜0.017). Conclusion Intravenous injection of 1.5 mg/kg lidocaine can effectively decrease the incidence of cough during the recovery period after bronchoscopy under general anesthesia, and also can significantly reduce the occurrences of nausea, vomiting and sore throat. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241208bronchoscopylidocainecoughlaryngeal mask anesthesiaadverse reaction |
| spellingShingle | KANG Cuiyao KANG Cuibi OU Xiaojing XIE Danru LI Feifei ZHANG Yiwen Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia Zhongguo linchuang yanjiu bronchoscopy lidocaine cough laryngeal mask anesthesia adverse reaction |
| title | Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| title_full | Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| title_fullStr | Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| title_full_unstemmed | Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| title_short | Effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| title_sort | effect of intravenous injection of different doses of lidocaine on cough during the recovery period after bronchoscopy under general anesthesia |
| topic | bronchoscopy lidocaine cough laryngeal mask anesthesia adverse reaction |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241208 |
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