Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken
This study examined the effect of the synbiotic product (PoultryStar®me) on Fayoumi and Cobb chickens upon exposure to Salmonella typhimurium (ST) infection and compared the responses of Fayoumi and Cobb chickens to ST infection. Fayoumi and Cobb chicks were fed synbiotic 1 g/kg feed from the first...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Italian Journal of Animal Science |
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| Online Access: | http://dx.doi.org/10.1080/1828051X.2024.2395855 |
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| author | Mohamed S. Elsharkawy Mohamed M. Abdelbaki Mahmoud Madkour Eman E. EL Shanawany Mohamad M. Aboelenin Qiao Wang Qinghe Li Guiping Zhao Jie Wen |
| author_facet | Mohamed S. Elsharkawy Mohamed M. Abdelbaki Mahmoud Madkour Eman E. EL Shanawany Mohamad M. Aboelenin Qiao Wang Qinghe Li Guiping Zhao Jie Wen |
| author_sort | Mohamed S. Elsharkawy |
| collection | DOAJ |
| description | This study examined the effect of the synbiotic product (PoultryStar®me) on Fayoumi and Cobb chickens upon exposure to Salmonella typhimurium (ST) infection and compared the responses of Fayoumi and Cobb chickens to ST infection. Fayoumi and Cobb chicks were fed synbiotic 1 g/kg feed from the first day. At 21 days of age, the chicks were orally challenged with 3 × 1012 cfu ST. At 72 h post-infection (pi), Fayoumi chickens showed significantly lower bacterial loads in their livers than Cobb chickens (p < 0.0001). Furthermore, the synbiotic reduced the bacterial load in the liver of both chicken types (p < 0.001). Moreover, the synbiotic product positively affected the plasma lysozyme content (p < 0.001) in both chicken types. The plasma IL-6 levels increased in the ST-challenged groups (p = 0.0003); moreover, the synbiotic reduced IL-6 levels in each type of chicken. The plasma IgG content increased only in the ST-challenged groups (p < 0.001) compared with the other groups. During ST infection, the synbiotic significantly decreased the proinflammatory cytokines expression including IL-8, IL-1β and TNF-α (p < 0.01) along with the frequency of TLR4 and MYD88 (p < 0.01) genes in both liver and spleen. Furthermore, Fayoumi chickens exhibited lower expression of these genes compared to Cobb chickens. Additionally, we found a significant interaction between chicken type and treatments, suggesting that different types of chickens may respond to pathogens differently. These findings indicate that the synbiotic can effectively modulate the host immune response to ST infection across different chicken types, with Fayoumi chickens demonstrating greater resistance to ST infection than Cobb chickens. |
| format | Article |
| id | doaj-art-ae80c08ebb8c4aa38a56bb8b5e377e1f |
| institution | Kabale University |
| issn | 1594-4077 1828-051X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj-art-ae80c08ebb8c4aa38a56bb8b5e377e1f2025-01-02T11:34:22ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2024-12-012311279128910.1080/1828051X.2024.23958552395855Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chickenMohamed S. Elsharkawy0Mohamed M. Abdelbaki1Mahmoud Madkour2Eman E. EL Shanawany3Mohamad M. Aboelenin4Qiao Wang5Qinghe Li6Guiping Zhao7Jie Wen8Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal NutritionPoultry Diseases Department, National Research CentreAnimal Production Department, National Research CentreParasitology and Animal Diseases Department, National Research CentreCell Biology Department, National Research CentreInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal NutritionInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal NutritionInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal NutritionInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal NutritionThis study examined the effect of the synbiotic product (PoultryStar®me) on Fayoumi and Cobb chickens upon exposure to Salmonella typhimurium (ST) infection and compared the responses of Fayoumi and Cobb chickens to ST infection. Fayoumi and Cobb chicks were fed synbiotic 1 g/kg feed from the first day. At 21 days of age, the chicks were orally challenged with 3 × 1012 cfu ST. At 72 h post-infection (pi), Fayoumi chickens showed significantly lower bacterial loads in their livers than Cobb chickens (p < 0.0001). Furthermore, the synbiotic reduced the bacterial load in the liver of both chicken types (p < 0.001). Moreover, the synbiotic product positively affected the plasma lysozyme content (p < 0.001) in both chicken types. The plasma IL-6 levels increased in the ST-challenged groups (p = 0.0003); moreover, the synbiotic reduced IL-6 levels in each type of chicken. The plasma IgG content increased only in the ST-challenged groups (p < 0.001) compared with the other groups. During ST infection, the synbiotic significantly decreased the proinflammatory cytokines expression including IL-8, IL-1β and TNF-α (p < 0.01) along with the frequency of TLR4 and MYD88 (p < 0.01) genes in both liver and spleen. Furthermore, Fayoumi chickens exhibited lower expression of these genes compared to Cobb chickens. Additionally, we found a significant interaction between chicken type and treatments, suggesting that different types of chickens may respond to pathogens differently. These findings indicate that the synbiotic can effectively modulate the host immune response to ST infection across different chicken types, with Fayoumi chickens demonstrating greater resistance to ST infection than Cobb chickens.http://dx.doi.org/10.1080/1828051X.2024.2395855fayoumicobb chickenssalmonella typhimuriumsynbioticgene expression |
| spellingShingle | Mohamed S. Elsharkawy Mohamed M. Abdelbaki Mahmoud Madkour Eman E. EL Shanawany Mohamad M. Aboelenin Qiao Wang Qinghe Li Guiping Zhao Jie Wen Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken Italian Journal of Animal Science fayoumi cobb chickens salmonella typhimurium synbiotic gene expression |
| title | Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken |
| title_full | Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken |
| title_fullStr | Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken |
| title_full_unstemmed | Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken |
| title_short | Synbiotic modulate the host immune response to Salmonella typhimurium infection in commercial and indigenous chicken |
| title_sort | synbiotic modulate the host immune response to salmonella typhimurium infection in commercial and indigenous chicken |
| topic | fayoumi cobb chickens salmonella typhimurium synbiotic gene expression |
| url | http://dx.doi.org/10.1080/1828051X.2024.2395855 |
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