Design of the Global Health chemical diversity library v2 for screening against infectious diseases.
There is a need for novel chemical matter for phenotypic and target-based screens to find starting points for drug discovery programmes in neglected infectious diseases and non-hormonal contraceptives that disproportionately affect Low- and Middle-Income Countries (LMICs). In some disease areas mult...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-12-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011799&type=printable |
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| _version_ | 1846128269140688896 |
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| author | Caroline Wilson J Mark F Gardner David W Gray Beatriz Baragana Paul G Wyatt Alex Cookson Stephen Thompson Cesar Mendoza-Martinez Michael J Bodkin Ian H Gilbert Gary J Tarver |
| author_facet | Caroline Wilson J Mark F Gardner David W Gray Beatriz Baragana Paul G Wyatt Alex Cookson Stephen Thompson Cesar Mendoza-Martinez Michael J Bodkin Ian H Gilbert Gary J Tarver |
| author_sort | Caroline Wilson |
| collection | DOAJ |
| description | There is a need for novel chemical matter for phenotypic and target-based screens to find starting points for drug discovery programmes in neglected infectious diseases and non-hormonal contraceptives that disproportionately affect Low- and Middle-Income Countries (LMICs). In some disease areas multiple screens of corporate and other libraries have been carried out, giving rise to some valuable starting points and leading to preclinical candidates. Whilst in other disease areas, little screening has been carried out. Much screening against pathogens has been conducted phenotypically as there are few robustly validated protein targets. However, many of the active compound series identified share the same molecular targets. To address the need for new chemical material, in this article we describe the design of a new library, designed for screening in drug discovery programmes for neglected infectious diseases. The compounds have been selected from the Enamine REAL (REadily AccessibLe) library, a virtual library which contains approximately 4.5 billion molecules. The molecules theoretically can be synthesized quickly using commercially available intermediates and building blocks. The vast majority of these have not been prepared before, so this is a source of novel compounds. In this paper we describe the design of a diverse library of 30,000 compounds from this collection (graphical abstract). The new library will be made available to laboratories working in neglected infectious diseases, subject to a review process. The project has been supported by the Bill & Melinda Gates Foundation and the Wellcome Trust (Wellcome). |
| format | Article |
| id | doaj-art-ae7dc23b661c42e4b35f3b3a4b1a1f7f |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-ae7dc23b661c42e4b35f3b3a4b1a1f7f2024-12-11T05:32:07ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-12-011712e001179910.1371/journal.pntd.0011799Design of the Global Health chemical diversity library v2 for screening against infectious diseases.Caroline WilsonJ Mark F GardnerDavid W GrayBeatriz BaraganaPaul G WyattAlex CooksonStephen ThompsonCesar Mendoza-MartinezMichael J BodkinIan H GilbertGary J TarverThere is a need for novel chemical matter for phenotypic and target-based screens to find starting points for drug discovery programmes in neglected infectious diseases and non-hormonal contraceptives that disproportionately affect Low- and Middle-Income Countries (LMICs). In some disease areas multiple screens of corporate and other libraries have been carried out, giving rise to some valuable starting points and leading to preclinical candidates. Whilst in other disease areas, little screening has been carried out. Much screening against pathogens has been conducted phenotypically as there are few robustly validated protein targets. However, many of the active compound series identified share the same molecular targets. To address the need for new chemical material, in this article we describe the design of a new library, designed for screening in drug discovery programmes for neglected infectious diseases. The compounds have been selected from the Enamine REAL (REadily AccessibLe) library, a virtual library which contains approximately 4.5 billion molecules. The molecules theoretically can be synthesized quickly using commercially available intermediates and building blocks. The vast majority of these have not been prepared before, so this is a source of novel compounds. In this paper we describe the design of a diverse library of 30,000 compounds from this collection (graphical abstract). The new library will be made available to laboratories working in neglected infectious diseases, subject to a review process. The project has been supported by the Bill & Melinda Gates Foundation and the Wellcome Trust (Wellcome).https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011799&type=printable |
| spellingShingle | Caroline Wilson J Mark F Gardner David W Gray Beatriz Baragana Paul G Wyatt Alex Cookson Stephen Thompson Cesar Mendoza-Martinez Michael J Bodkin Ian H Gilbert Gary J Tarver Design of the Global Health chemical diversity library v2 for screening against infectious diseases. PLoS Neglected Tropical Diseases |
| title | Design of the Global Health chemical diversity library v2 for screening against infectious diseases. |
| title_full | Design of the Global Health chemical diversity library v2 for screening against infectious diseases. |
| title_fullStr | Design of the Global Health chemical diversity library v2 for screening against infectious diseases. |
| title_full_unstemmed | Design of the Global Health chemical diversity library v2 for screening against infectious diseases. |
| title_short | Design of the Global Health chemical diversity library v2 for screening against infectious diseases. |
| title_sort | design of the global health chemical diversity library v2 for screening against infectious diseases |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011799&type=printable |
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