On dissolution test for Hypertril tablets using high performance liquid chromatography
Particular attention is paid to the release of the active ingredients of drugs in the form of tablets. Therefore, we have developed a method for determining the dissolution test, for the original drug Hypertril. The purpose. To develop a methodology for dissolution test for Hypertril tablets with...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2019-03-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/158991/158810 |
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| _version_ | 1849245350721748992 |
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| author | L. I. Kucherenko N. V. Parniuk Z. B. Moriak L. H. Cherkovska H. I. Tkachenko |
| author_facet | L. I. Kucherenko N. V. Parniuk Z. B. Moriak L. H. Cherkovska H. I. Tkachenko |
| author_sort | L. I. Kucherenko |
| collection | DOAJ |
| description | Particular attention is paid to the release of the active ingredients of drugs in the form of tablets. Therefore, we have developed a method for determining the dissolution test, for the original drug Hypertril.
The purpose. To develop a methodology for dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method.
Materials and methods. In the studies we used Hypertril tablets with an active substance content of 20 mg, obtained in the Standardization and Drug Technology Laboratory at the Pharmaceutical Chemistry Department of ZSMU. A standard sample of the hypertril substance was received from the State Enterprise “Chemical Reagents Plant” (Kharkiv, Ukraine). We used high-performance liquid chromatograph Bishoff with an UV detector for studies. During the dissolution test of the Hypertril tablets, a device with a blade from the company Pharma Test PTWS 120D, Germany, was used.
Results. As a result of the conducted studies, the chromatograms were obtained. Having analyzed the chromatograms, we proved that the method is highly sensitive and accurate and can be used to determine the dissolution test. The obtained study results showed that the amount of the active substance that passed into the solution from the Hypertril tablets after 45 minutes and is from 91.2 to 99.6 %, that meets the requirements of the State Pharmacopoeia of Ukraine.
Conclusions. In the course of study, we developed a method for carrying out the dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method. The study results confirm that the developed method is accurate and reliable. |
| format | Article |
| id | doaj-art-ae616cdc90ed40c1aa81f85624d5a47e |
| institution | Kabale University |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-ae616cdc90ed40c1aa81f85624d5a47e2025-08-20T03:58:50ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322019-03-01211424610.14739/2409-2932.2019.1.158991On dissolution test for Hypertril tablets using high performance liquid chromatographyL. I. KucherenkoN. V. ParniukZ. B. MoriakL. H. CherkovskaH. I. TkachenkoParticular attention is paid to the release of the active ingredients of drugs in the form of tablets. Therefore, we have developed a method for determining the dissolution test, for the original drug Hypertril. The purpose. To develop a methodology for dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method. Materials and methods. In the studies we used Hypertril tablets with an active substance content of 20 mg, obtained in the Standardization and Drug Technology Laboratory at the Pharmaceutical Chemistry Department of ZSMU. A standard sample of the hypertril substance was received from the State Enterprise “Chemical Reagents Plant” (Kharkiv, Ukraine). We used high-performance liquid chromatograph Bishoff with an UV detector for studies. During the dissolution test of the Hypertril tablets, a device with a blade from the company Pharma Test PTWS 120D, Germany, was used. Results. As a result of the conducted studies, the chromatograms were obtained. Having analyzed the chromatograms, we proved that the method is highly sensitive and accurate and can be used to determine the dissolution test. The obtained study results showed that the amount of the active substance that passed into the solution from the Hypertril tablets after 45 minutes and is from 91.2 to 99.6 %, that meets the requirements of the State Pharmacopoeia of Ukraine. Conclusions. In the course of study, we developed a method for carrying out the dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method. The study results confirm that the developed method is accurate and reliable.http://pharmed.zsmu.edu.ua/article/view/158991/158810hypertriltabletsdrug liberationliquid high pressure chromatography |
| spellingShingle | L. I. Kucherenko N. V. Parniuk Z. B. Moriak L. H. Cherkovska H. I. Tkachenko On dissolution test for Hypertril tablets using high performance liquid chromatography Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki hypertril tablets drug liberation liquid high pressure chromatography |
| title | On dissolution test for Hypertril tablets using high performance liquid chromatography |
| title_full | On dissolution test for Hypertril tablets using high performance liquid chromatography |
| title_fullStr | On dissolution test for Hypertril tablets using high performance liquid chromatography |
| title_full_unstemmed | On dissolution test for Hypertril tablets using high performance liquid chromatography |
| title_short | On dissolution test for Hypertril tablets using high performance liquid chromatography |
| title_sort | on dissolution test for hypertril tablets using high performance liquid chromatography |
| topic | hypertril tablets drug liberation liquid high pressure chromatography |
| url | http://pharmed.zsmu.edu.ua/article/view/158991/158810 |
| work_keys_str_mv | AT likucherenko ondissolutiontestforhypertriltabletsusinghighperformanceliquidchromatography AT nvparniuk ondissolutiontestforhypertriltabletsusinghighperformanceliquidchromatography AT zbmoriak ondissolutiontestforhypertriltabletsusinghighperformanceliquidchromatography AT lhcherkovska ondissolutiontestforhypertriltabletsusinghighperformanceliquidchromatography AT hitkachenko ondissolutiontestforhypertriltabletsusinghighperformanceliquidchromatography |