Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia

Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia

Abstract Background Chronic neuroinflammation, driven by M1-polarized microglia, is a core pathological mechanism of Alzheimer’s disease (AD). Elevated expression levels of miR-199a-3p and pro-inflammatory cytokines were detected in the hippocampi of AD transgenic mice and in LPS-stimulated BV2 micr...

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Bibliographic Details
Main Authors: Chenyang Wang, Xiaolu Bu, Mengyao Cao, Yunyu Lian, Haocong Ling, Mo You, Junfei Yi, Xiaoya Gao, Duobin Wu, Yang Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neuroscience
Subjects:
MiR-199a-3p
Alzheimer’s disease
Neuroinflammation
Microglia
Online Access:https://doi.org/10.1186/s12868-025-00965-5
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https://doi.org/10.1186/s12868-025-00965-5

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