Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors

<b>Background/Objectives</b>: The proton-coupled amino acid transporter (PAT1) is an intestinal absorptive solute carrier responsible for the oral bioavailability of some GABA-mimetic drug substances such as vigabatrin and gaboxadol. In the present work, we investigate if non-steroidal a...

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Bibliographic Details
Main Authors: Carsten Uhd Nielsen, Sebastian Jakobsen, Maria L. Pedersen
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceutics
Subjects:
hPAT1
human proton-coupled amino acid transporter
NSAIDs
ibuprofen
inhibitor
Caco-2
Online Access:https://www.mdpi.com/1999-4923/17/1/49
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