Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients
Objectives To examine the effects of high-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) on the cognitive function of hemodialysis (HD) patients, and to explore the relationship between hs-CRP, LVH, and cognitive impairment (CI).Methods A cross-sectional study was con...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2450522 |
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| author | Yu Zhang Yu-lu Gu Wan-fen Zhang Xiao-ping Li Lin-fang Xu Tong-qiang Liu |
| author_facet | Yu Zhang Yu-lu Gu Wan-fen Zhang Xiao-ping Li Lin-fang Xu Tong-qiang Liu |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Objectives To examine the effects of high-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) on the cognitive function of hemodialysis (HD) patients, and to explore the relationship between hs-CRP, LVH, and cognitive impairment (CI).Methods A cross-sectional study was conducted on 232 HD patients. Besides, general clinical data were gathered, and patients’ cognitive functions were assessed using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ). CI risk factors were screened using logistic regression modeling based on hs-CRP values (low risk <1 mg/L, intermediate risk 1–3 mg/L, and high risk >3 mg/L) and LVH status (normal and hypertrophic) groupings. The synergistic effect of hs-CRP and LVH on CI was also analyzed using the EpiR package.Results Among HD patients, 122 (52.59%) patients had CI. Multifactorial logistic regression analysis showed that the following factors were associated with an increased risk of CI in HD patients: age (OR = 1.048; 95% CI 1.014–1.083; p = 0.005), LVH (OR = 3.741; 95% CI 1.828–7.657; p < 0.001), and high-risk hs-CRP levels (>3 mg/L; OR = 3.238; 95% CI 1.349–7.768; p = 0.009). In addition, there was a significant synergy between hs-CRP high risk (>3 mg/L) and LVH.Conclusion Age, LVH, and high risk of hs-CRP (>3 mg/L) were independent risk factors for CI in HD patients. Moreover, HD patients with both hs-CRP high risk (>3.0 mg/L) and LVH were at higher risk of developing CI, and lowering hs-CRP levels and preventing LVH may prevent CI. |
| format | Article |
| id | doaj-art-ae324412c01f4a738562715bceb5da4c |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-ae324412c01f4a738562715bceb5da4c2025-01-17T06:35:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2450522Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patientsYu Zhang0Yu-lu Gu1Wan-fen Zhang2Xiao-ping Li3Lin-fang Xu4Tong-qiang Liu5Department of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaDepartment of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaDepartment of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaDepartment of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaDepartment of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaDepartment of Nephrology, the Affiliated Changzhou Second People’s Hospital with Nanjing Medical University, Changzhou, ChinaObjectives To examine the effects of high-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) on the cognitive function of hemodialysis (HD) patients, and to explore the relationship between hs-CRP, LVH, and cognitive impairment (CI).Methods A cross-sectional study was conducted on 232 HD patients. Besides, general clinical data were gathered, and patients’ cognitive functions were assessed using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ). CI risk factors were screened using logistic regression modeling based on hs-CRP values (low risk <1 mg/L, intermediate risk 1–3 mg/L, and high risk >3 mg/L) and LVH status (normal and hypertrophic) groupings. The synergistic effect of hs-CRP and LVH on CI was also analyzed using the EpiR package.Results Among HD patients, 122 (52.59%) patients had CI. Multifactorial logistic regression analysis showed that the following factors were associated with an increased risk of CI in HD patients: age (OR = 1.048; 95% CI 1.014–1.083; p = 0.005), LVH (OR = 3.741; 95% CI 1.828–7.657; p < 0.001), and high-risk hs-CRP levels (>3 mg/L; OR = 3.238; 95% CI 1.349–7.768; p = 0.009). In addition, there was a significant synergy between hs-CRP high risk (>3 mg/L) and LVH.Conclusion Age, LVH, and high risk of hs-CRP (>3 mg/L) were independent risk factors for CI in HD patients. Moreover, HD patients with both hs-CRP high risk (>3.0 mg/L) and LVH were at higher risk of developing CI, and lowering hs-CRP levels and preventing LVH may prevent CI.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2450522Hemodialysiscognitive impairmenthigh-sensitivity C-reactive proteinleft ventricular hypertrophysynergy |
| spellingShingle | Yu Zhang Yu-lu Gu Wan-fen Zhang Xiao-ping Li Lin-fang Xu Tong-qiang Liu Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients Renal Failure Hemodialysis cognitive impairment high-sensitivity C-reactive protein left ventricular hypertrophy synergy |
| title | Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| title_full | Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| title_fullStr | Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| title_full_unstemmed | Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| title_short | Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| title_sort | effects of high sensitivity c reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis patients |
| topic | Hemodialysis cognitive impairment high-sensitivity C-reactive protein left ventricular hypertrophy synergy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2450522 |
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