Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review
Chitinase-3-like protein 1 (CHI3L1) is part of the glycoside hydrolase family 18. Despite lacking enzymatic activity, its unique structure allows it to bind to ligands, altering its steric configuration to mediate cell proliferation, inflammation, fibrosis, and carcinogenesis. In liver disease, CHI3...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304225001424 |
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| author | Chao Tian Shizhou Deng Ming Yang Baochen Bai Lai Wei |
| author_facet | Chao Tian Shizhou Deng Ming Yang Baochen Bai Lai Wei |
| author_sort | Chao Tian |
| collection | DOAJ |
| description | Chitinase-3-like protein 1 (CHI3L1) is part of the glycoside hydrolase family 18. Despite lacking enzymatic activity, its unique structure allows it to bind to ligands, altering its steric configuration to mediate cell proliferation, inflammation, fibrosis, and carcinogenesis. In liver disease, CHI3L1 serves as a common diagnostic biomarker for hepatitis-related fibrosis. Additionally, CHI3L1 can predict the risk of non-alcoholic steatohepatitis, the progression of hepatic fibrosis, and the prognosis of alcoholic liver disease and hepatocellular carcinoma. It also aids in diagnosing and staging non-alcoholic fatty liver disease-related and alcoholic liver disease-related fibrosis, and in monitoring hepatitis-related fibrosis treatment. Furthermore, CHI3L1 is secreted by various cells, including hepatocytes, hepatic stellate cells, macrophages, and mesenchymal stem cells, to regulate hepatic injury, fibrosis, steatosis, and hepatocellular carcinoma through different signaling pathways. This review highlights CHI3L1's dual roles as both a biomarker and regulator in various liver diseases, aiming to broaden researchers' understanding of its potential applications. |
| format | Article |
| id | doaj-art-ae2effc620ce4fc2ac84cfdb3d0d74e6 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-ae2effc620ce4fc2ac84cfdb3d0d74e62025-08-24T05:13:14ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-11-0112610165310.1016/j.gendis.2025.101653Role of chitinase-3-like protein 1 in liver diseases: A comprehensive reviewChao Tian0Shizhou Deng1Ming Yang2Baochen Bai3Lai Wei4Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, ChinaHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, China; Research and Development Department, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong 510700, ChinaHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, ChinaDepartment of Cardiology, Peking University People's Hospital, Beijing 100044, ChinaHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, China; Corresponding author. Hepatopancreatobiliary Center, Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.Chitinase-3-like protein 1 (CHI3L1) is part of the glycoside hydrolase family 18. Despite lacking enzymatic activity, its unique structure allows it to bind to ligands, altering its steric configuration to mediate cell proliferation, inflammation, fibrosis, and carcinogenesis. In liver disease, CHI3L1 serves as a common diagnostic biomarker for hepatitis-related fibrosis. Additionally, CHI3L1 can predict the risk of non-alcoholic steatohepatitis, the progression of hepatic fibrosis, and the prognosis of alcoholic liver disease and hepatocellular carcinoma. It also aids in diagnosing and staging non-alcoholic fatty liver disease-related and alcoholic liver disease-related fibrosis, and in monitoring hepatitis-related fibrosis treatment. Furthermore, CHI3L1 is secreted by various cells, including hepatocytes, hepatic stellate cells, macrophages, and mesenchymal stem cells, to regulate hepatic injury, fibrosis, steatosis, and hepatocellular carcinoma through different signaling pathways. This review highlights CHI3L1's dual roles as both a biomarker and regulator in various liver diseases, aiming to broaden researchers' understanding of its potential applications.http://www.sciencedirect.com/science/article/pii/S2352304225001424Chitinase-3-like protein 1Hepatic fibrosisHepatocellular carcinomaLiver disease biomarkerNon-alcoholic steatohepatitisSignaling pathways |
| spellingShingle | Chao Tian Shizhou Deng Ming Yang Baochen Bai Lai Wei Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review Genes and Diseases Chitinase-3-like protein 1 Hepatic fibrosis Hepatocellular carcinoma Liver disease biomarker Non-alcoholic steatohepatitis Signaling pathways |
| title | Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review |
| title_full | Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review |
| title_fullStr | Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review |
| title_full_unstemmed | Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review |
| title_short | Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review |
| title_sort | role of chitinase 3 like protein 1 in liver diseases a comprehensive review |
| topic | Chitinase-3-like protein 1 Hepatic fibrosis Hepatocellular carcinoma Liver disease biomarker Non-alcoholic steatohepatitis Signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2352304225001424 |
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