DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules
Lung cancer remains a leading cause of cancer-related mortality worldwide, and accurate early identification of malignant pulmonary nodules is critical for improving patient outcomes. Although artificial intelligence (AI) technology has shown promise in pulmonary nodule benign-malignant classificati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1636008/full |
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| author | Shuling Wang Suixue Wang Rongdao Sun |
| author_facet | Shuling Wang Suixue Wang Rongdao Sun |
| author_sort | Shuling Wang |
| collection | DOAJ |
| description | Lung cancer remains a leading cause of cancer-related mortality worldwide, and accurate early identification of malignant pulmonary nodules is critical for improving patient outcomes. Although artificial intelligence (AI) technology has shown promise in pulmonary nodule benign-malignant classification, existing methods struggle with modality heterogeneity and limited exploitation of complementary information across modalities. To address the above issues, we propose a novel multimodal framework, the Dual Cross-Attention Integration framework (DCAI), for benign-malignant classification of pulmonary nodules. Specifically, we first convert 3D nodules into multiple 2D images and obtain nodule features annotated by clinical experts. These features are encoded using Transformer models, and then a dual cross-attention module is proposed to dynamically align and interact with the complementary information between the different modalities. The fused representations from both modalities are then concatenated for benign-malignant prediction. We evaluate our proposed method on the LIDC-IDRI dataset, and experimental results demonstrate that DCAI outperforms several existing multimodal methods, highlighting the effectiveness of our approach in improving the accuracy of pulmonary nodule benign-malignant classification. |
| format | Article |
| id | doaj-art-ae07ac0cfc634f7fa68d1b6e35e236b2 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-ae07ac0cfc634f7fa68d1b6e35e236b22025-08-20T03:51:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16360081636008DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodulesShuling Wang0Suixue Wang1Rongdao Sun2Department of Neurology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, ChinaSchool of Computer Science and Technology, Hainan University, Haikou, ChinaDepartment of Neurology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, ChinaLung cancer remains a leading cause of cancer-related mortality worldwide, and accurate early identification of malignant pulmonary nodules is critical for improving patient outcomes. Although artificial intelligence (AI) technology has shown promise in pulmonary nodule benign-malignant classification, existing methods struggle with modality heterogeneity and limited exploitation of complementary information across modalities. To address the above issues, we propose a novel multimodal framework, the Dual Cross-Attention Integration framework (DCAI), for benign-malignant classification of pulmonary nodules. Specifically, we first convert 3D nodules into multiple 2D images and obtain nodule features annotated by clinical experts. These features are encoded using Transformer models, and then a dual cross-attention module is proposed to dynamically align and interact with the complementary information between the different modalities. The fused representations from both modalities are then concatenated for benign-malignant prediction. We evaluate our proposed method on the LIDC-IDRI dataset, and experimental results demonstrate that DCAI outperforms several existing multimodal methods, highlighting the effectiveness of our approach in improving the accuracy of pulmonary nodule benign-malignant classification.https://www.frontiersin.org/articles/10.3389/fmed.2025.1636008/fullpulmonary nodulebenign-malignant classificationartificial intelligencemultimodalcross-attentiontransformer |
| spellingShingle | Shuling Wang Suixue Wang Rongdao Sun DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules Frontiers in Medicine pulmonary nodule benign-malignant classification artificial intelligence multimodal cross-attention transformer |
| title | DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules |
| title_full | DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules |
| title_fullStr | DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules |
| title_full_unstemmed | DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules |
| title_short | DCAI: a dual cross-attention integration framework for benign-malignant classification of pulmonary nodules |
| title_sort | dcai a dual cross attention integration framework for benign malignant classification of pulmonary nodules |
| topic | pulmonary nodule benign-malignant classification artificial intelligence multimodal cross-attention transformer |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1636008/full |
| work_keys_str_mv | AT shulingwang dcaiadualcrossattentionintegrationframeworkforbenignmalignantclassificationofpulmonarynodules AT suixuewang dcaiadualcrossattentionintegrationframeworkforbenignmalignantclassificationofpulmonarynodules AT rongdaosun dcaiadualcrossattentionintegrationframeworkforbenignmalignantclassificationofpulmonarynodules |