Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study
Abstract Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functiona...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-024-00536-3 |
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| author | Jianmeng Song Edgardo Carmona-Torres Yasaman Kambari Sofia Chavez Fumihiko Ueno Teruki Koizum Aron Amaev Ali Abdolizadeh Vincenzo De Luca Daniel M. Blumberger Gary Remington Bruce Pollock Ariel Graff-Guerrero Philip Gerretsen |
| author_facet | Jianmeng Song Edgardo Carmona-Torres Yasaman Kambari Sofia Chavez Fumihiko Ueno Teruki Koizum Aron Amaev Ali Abdolizadeh Vincenzo De Luca Daniel M. Blumberger Gary Remington Bruce Pollock Ariel Graff-Guerrero Philip Gerretsen |
| author_sort | Jianmeng Song |
| collection | DOAJ |
| description | Abstract Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. To date, limited studies have investigated the association between regional cerebral blood flow (CBF) and impaired insight in schizophrenia. Therefore, we sought to investigate the relationship between regional CBF, as measured by arterial spin labeling (ASL), and impaired insight in participants with schizophrenia. A total of 32 participants were included in the analysis. Impaired insight in patients with schizophrenia was measured using the VAGUS, Self-report (VAGUS-SR). Resting-state regional CBF was measured using pseudo-continuous ASL (pCASL) and extracted using SPM12 and REX toolbox. Whole brain analysis found that impaired insight was associated with higher regional CBF in the right angular gyrus, left supramarginal gyrus, and right superior frontal region when controlling for age, gender, smoking status, and illness severity. The results indicate that impaired insight in schizophrenia is related to regional CBF in frontoparietal areas. These neuroimaging findings can serve as therapeutic targets for intervention, such as with non-invasive brain stimulation. |
| format | Article |
| id | doaj-art-adff752f2609486295570e433671c411 |
| institution | Kabale University |
| issn | 2754-6993 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-adff752f2609486295570e433671c4112025-01-12T12:28:06ZengNature PortfolioSchizophrenia2754-69932025-01-011111910.1038/s41537-024-00536-3Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling studyJianmeng Song0Edgardo Carmona-Torres1Yasaman Kambari2Sofia Chavez3Fumihiko Ueno4Teruki Koizum5Aron Amaev6Ali Abdolizadeh7Vincenzo De Luca8Daniel M. Blumberger9Gary Remington10Bruce Pollock11Ariel Graff-Guerrero12Philip Gerretsen13Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Institute of Medical Science, University of TorontoMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Institute of Medical Science, University of TorontoInstitute of Medical Science, University of TorontoInstitute of Medical Science, University of TorontoInstitute of Medical Science, University of TorontoMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH)Abstract Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. To date, limited studies have investigated the association between regional cerebral blood flow (CBF) and impaired insight in schizophrenia. Therefore, we sought to investigate the relationship between regional CBF, as measured by arterial spin labeling (ASL), and impaired insight in participants with schizophrenia. A total of 32 participants were included in the analysis. Impaired insight in patients with schizophrenia was measured using the VAGUS, Self-report (VAGUS-SR). Resting-state regional CBF was measured using pseudo-continuous ASL (pCASL) and extracted using SPM12 and REX toolbox. Whole brain analysis found that impaired insight was associated with higher regional CBF in the right angular gyrus, left supramarginal gyrus, and right superior frontal region when controlling for age, gender, smoking status, and illness severity. The results indicate that impaired insight in schizophrenia is related to regional CBF in frontoparietal areas. These neuroimaging findings can serve as therapeutic targets for intervention, such as with non-invasive brain stimulation.https://doi.org/10.1038/s41537-024-00536-3 |
| spellingShingle | Jianmeng Song Edgardo Carmona-Torres Yasaman Kambari Sofia Chavez Fumihiko Ueno Teruki Koizum Aron Amaev Ali Abdolizadeh Vincenzo De Luca Daniel M. Blumberger Gary Remington Bruce Pollock Ariel Graff-Guerrero Philip Gerretsen Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study Schizophrenia |
| title | Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study |
| title_full | Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study |
| title_fullStr | Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study |
| title_full_unstemmed | Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study |
| title_short | Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study |
| title_sort | impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow an arterial spin labeling study |
| url | https://doi.org/10.1038/s41537-024-00536-3 |
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