Heavily treatment-experienced patients with HIV: are new mechanisms of action enough?
Antiretroviral (ARV) drug resistance poses a threat to ending the HIV epidemic. As the rates of integrase resistance continue to increase globally, the availability of options for HIV treatment becomes limited. Heavily treatment-experienced (HTE) people with HIV (PWH) are limited to two or fewer ava...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-12-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241301883 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846140367671394304 |
|---|---|
| author | Marisa B. Brizzi Tracy L. Cable Dimple C. Patel Kelli Williams Zoe Adjei Carl J. Fichtenbaum |
| author_facet | Marisa B. Brizzi Tracy L. Cable Dimple C. Patel Kelli Williams Zoe Adjei Carl J. Fichtenbaum |
| author_sort | Marisa B. Brizzi |
| collection | DOAJ |
| description | Antiretroviral (ARV) drug resistance poses a threat to ending the HIV epidemic. As the rates of integrase resistance continue to increase globally, the availability of options for HIV treatment becomes limited. Heavily treatment-experienced (HTE) people with HIV (PWH) are limited to two or fewer available fully active ARV classes and are more likely to have an AIDS-defining event. Appropriate identification and management of HTE PWH is crucial to improving patient outcomes and reducing the future spread of drug-resistant HIV. As treatment options become more limited owing to drug resistance, the availability of more potent drugs with a marked increase in virologic suppression is needed in the current ART era. The purpose of this narrative review is to review the identification of HTE PWH, novel mechanisms of resistance, and management of HTE PWH in resource-rich and resource-limited settings using novel ARVs and combination ART. |
| format | Article |
| id | doaj-art-adf898d62ada4bfdbbee8c86af985d87 |
| institution | Kabale University |
| issn | 1473-2300 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-adf898d62ada4bfdbbee8c86af985d872024-12-05T13:03:54ZengSAGE PublishingJournal of International Medical Research1473-23002024-12-015210.1177/03000605241301883Heavily treatment-experienced patients with HIV: are new mechanisms of action enough?Marisa B. BrizziTracy L. CableDimple C. PatelKelli WilliamsZoe AdjeiCarl J. FichtenbaumAntiretroviral (ARV) drug resistance poses a threat to ending the HIV epidemic. As the rates of integrase resistance continue to increase globally, the availability of options for HIV treatment becomes limited. Heavily treatment-experienced (HTE) people with HIV (PWH) are limited to two or fewer available fully active ARV classes and are more likely to have an AIDS-defining event. Appropriate identification and management of HTE PWH is crucial to improving patient outcomes and reducing the future spread of drug-resistant HIV. As treatment options become more limited owing to drug resistance, the availability of more potent drugs with a marked increase in virologic suppression is needed in the current ART era. The purpose of this narrative review is to review the identification of HTE PWH, novel mechanisms of resistance, and management of HTE PWH in resource-rich and resource-limited settings using novel ARVs and combination ART.https://doi.org/10.1177/03000605241301883 |
| spellingShingle | Marisa B. Brizzi Tracy L. Cable Dimple C. Patel Kelli Williams Zoe Adjei Carl J. Fichtenbaum Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? Journal of International Medical Research |
| title | Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? |
| title_full | Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? |
| title_fullStr | Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? |
| title_full_unstemmed | Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? |
| title_short | Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? |
| title_sort | heavily treatment experienced patients with hiv are new mechanisms of action enough |
| url | https://doi.org/10.1177/03000605241301883 |
| work_keys_str_mv | AT marisabbrizzi heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough AT tracylcable heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough AT dimplecpatel heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough AT kelliwilliams heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough AT zoeadjei heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough AT carljfichtenbaum heavilytreatmentexperiencedpatientswithhivarenewmechanismsofactionenough |