Research progress of Toll-like receptors in calcified aortic valve disease
Calcified aortic valve disease (CAVD) was believed to be caused by aging-associated degenerative changes and passive calcium deposition. In recent years, it has been found that CAVD is an active pathological process, but the possible pathogenesis of CAVD has not been elucidated. During the developme...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2024-02-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2403/qjoZPXe0RDUDzvIoiTPhzR5RZ3PS9IrBSb5nOk4b.pdf |
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| _version_ | 1846110343989821440 |
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| author | REN Yiming ZHANG Jinhui WANG Congcong WANG Tiankun REN Xuequn ZHOU Jianliang |
| author_facet | REN Yiming ZHANG Jinhui WANG Congcong WANG Tiankun REN Xuequn ZHOU Jianliang |
| author_sort | REN Yiming |
| collection | DOAJ |
| description | Calcified aortic valve disease (CAVD) was believed to be caused by aging-associated degenerative changes and passive calcium deposition. In recent years, it has been found that CAVD is an active pathological process, but the possible pathogenesis of CAVD has not been elucidated. During the development of CAVD, both innate and adaptive immune responses are activated, and increasing evidence suggests that inflammation plays a central role in the initiation and progression of the disease, in which the function of Toll-like receptors (TLRs) is particularly important. TLRs play a crucial role in controlling infection and maintaining tissue homeostasis by identifying host derived molecules released after pathogen and tissue damage, acting as a sentinel for the innate immune system. This article provides an overview of the current concepts regarding the relationship between TLRs signaling and inflammation and calcification remodeling in the pathogenesis of CAVD. The above regulatory mechanisms can provide new targets and strategies for the treatment of CAVD. |
| format | Article |
| id | doaj-art-adc7766b2ec34b0b85a4902efa9a94f2 |
| institution | Kabale University |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2024-02-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-adc7766b2ec34b0b85a4902efa9a94f22024-12-24T08:59:08ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112024-02-0134221722510.12173/j.issn.1004-5511.2023120356447Research progress of Toll-like receptors in calcified aortic valve diseaseREN YimingZHANG JinhuiWANG CongcongWANG TiankunREN XuequnZHOU JianliangCalcified aortic valve disease (CAVD) was believed to be caused by aging-associated degenerative changes and passive calcium deposition. In recent years, it has been found that CAVD is an active pathological process, but the possible pathogenesis of CAVD has not been elucidated. During the development of CAVD, both innate and adaptive immune responses are activated, and increasing evidence suggests that inflammation plays a central role in the initiation and progression of the disease, in which the function of Toll-like receptors (TLRs) is particularly important. TLRs play a crucial role in controlling infection and maintaining tissue homeostasis by identifying host derived molecules released after pathogen and tissue damage, acting as a sentinel for the innate immune system. This article provides an overview of the current concepts regarding the relationship between TLRs signaling and inflammation and calcification remodeling in the pathogenesis of CAVD. The above regulatory mechanisms can provide new targets and strategies for the treatment of CAVD.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2403/qjoZPXe0RDUDzvIoiTPhzR5RZ3PS9IrBSb5nOk4b.pdfcalcified aortic valve diseasetoll-like receptorthe inflammatory response |
| spellingShingle | REN Yiming ZHANG Jinhui WANG Congcong WANG Tiankun REN Xuequn ZHOU Jianliang Research progress of Toll-like receptors in calcified aortic valve disease Yixue xinzhi zazhi calcified aortic valve disease toll-like receptor the inflammatory response |
| title | Research progress of Toll-like receptors in calcified aortic valve disease |
| title_full | Research progress of Toll-like receptors in calcified aortic valve disease |
| title_fullStr | Research progress of Toll-like receptors in calcified aortic valve disease |
| title_full_unstemmed | Research progress of Toll-like receptors in calcified aortic valve disease |
| title_short | Research progress of Toll-like receptors in calcified aortic valve disease |
| title_sort | research progress of toll like receptors in calcified aortic valve disease |
| topic | calcified aortic valve disease toll-like receptor the inflammatory response |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2403/qjoZPXe0RDUDzvIoiTPhzR5RZ3PS9IrBSb5nOk4b.pdf |
| work_keys_str_mv | AT renyiming researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease AT zhangjinhui researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease AT wangcongcong researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease AT wangtiankun researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease AT renxuequn researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease AT zhoujianliang researchprogressoftolllikereceptorsincalcifiedaorticvalvedisease |