Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC

Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC

IntroductionThe role of mast cells (MCs) in clear cell renal carcinoma (ccRCC) is unclear, and comprehensive single-cell studies of ccRCC MCs have not yet been performed.MethodsTo investigate the heterogeneity and effects of MCs in ccRCC, we studied single-cell transcriptomes from four ccRCC patient...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiyu Song, Jianhua Jiao, Jiayang Qin, Wei Zhang, Weijun Qin, Shuaijun Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	mast cell clear cell renal cell carcinoma single-cell RNA sequencing heterogeneity spatial transcriptomics prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494025/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction
by: Fang Lyu, et al.
Published: (2025-01-01)

Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC
by: Xiangxian Che, et al.
Published: (2024-11-01)

Transient degradation of NF-κB proteins in macrophages after interaction with mast cell granules
by: Noriko Ito, et al.
Published: (1998-01-01)

Mast cell mediated myofibroblast differentiation responsible for progression of oral submucous fibrosis
by: Mamatha GS Reddy, et al.
Published: (2024-03-01)

Distribution and heterogeneity of mast cells in different regions of the genital canal in female quails during the prepubertal and postpubertal periods
by: Nariste Kadyralieva, et al.
Published: (2022-12-01)

Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1
by: Roberto André Torres de Vasconcelos, et al.
Published: (2019-03-01)

Differential regulation of the release of tumor necrosis factor-α and of eicosanoids by mast cells in rat airways after antigen challenge
by: Aryene Goes Trezena, et al.
Published: (2003-01-01)

Role of mast cell in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
by: Masaaki Nishi, et al.
Published: (2025-01-01)

Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison
by: Yeji Kim, et al.
Published: (2025-01-01)

Characterization of patients with clonal mast cells in the bone marrow with clinical significance not otherwise specifiedResearch in context
by: Thomas Ballul, et al.
Published: (2025-02-01)

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy
by: Dylan Krajewski, et al.
Published: (2025-01-01)

Bladder Metastasis from Clear Cell Renal Cell Carcinoma: A Case Report
by: İlkin Hamid-Zada, et al.
Published: (2024-07-01)

Role of CD117 and mast cells in periodontal diseases: Histological and immunohistochemical study
by: Fatin L. Khaphi, et al.
Published: (2025-03-01)

Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase
by: Bright Obeng, et al.
Published: (2024-12-01)

Clinical outcomes of dogs with high-grade cutaneous mast cell tumors
by: Siew Mei Ong, et al.
Published: (2025-01-01)

RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis
by: Jing Ma, et al.
Published: (2025-12-01)

Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
by: Song Shengyou, et al.
Published: (2025-02-01)

Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma
by: Dinh-Xuan Pham, et al.
Published: (2025-02-01)

Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics
by: Ramya Ramadoss, et al.
Published: (2024-03-01)

Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia
by: Anthony E. Kincaid, et al.
Published: (2024-12-01)

Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma
by: Liuyan Chen, et al.
Published: (2025-01-01)

Integrated RNA sequencing analysis and machine learning identifies a metabolism-related prognostic signature in clear cell renal cell carcinoma
by: Yunxun Liu, et al.
Published: (2025-01-01)

Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients
by: Yiliang Meng, et al.
Published: (2021-01-01)

Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis
by: Hongyun Wang, et al.
Published: (2025-01-01)

FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma
by: Jian Chen, et al.
Published: (2025-01-01)

Single cell transcriptomics in blood of patients with chronic obstructive pulmonary disease
by: Yeonjeong Heo, et al.
Published: (2025-01-01)

Single-cell and spatial transcriptomics reveal SPP1-CD44 signaling drives primary resistance to immune checkpoint inhibitors in RCC
by: Junfeng Zhang, et al.
Published: (2024-12-01)

Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma
by: Yong Xiao, et al.
Published: (2025-01-01)

Pseudoxanthomatous Mastocytosis: A Rare Variant in a Hispanic Male
by: Anabell Andrea Lima-Galindo, et al.
Published: (2025-01-01)

Single-cell and spatial transcriptomics in endocrine research
by: Ryusaku Matsumoto, et al.
Published: (2024-02-01)

Case report: Tongue metastasis as an initial sign of clear cell renal cell carcinoma and its prognosis
by: Shuo Liu, et al.
Published: (2025-01-01)

Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape
by: Silke De Vriendt, et al.
Published: (2025-02-01)

Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics
by: Xinying Zhang, et al.
Published: (2025-01-01)

Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model
by: Atsushi Mima, et al.
Published: (2025-02-01)

Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells
by: Nibedita Mitra, et al.
Published: (2025-01-01)

Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data
by: Jinming Cheng, et al.
Published: (2025-01-01)

Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity
by: C. Haberl, et al.
Published: (1998-01-01)

CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma
by: Kangkang Yang, et al.
Published: (2025-01-01)

Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma
by: Xiaqin Zhang, et al.
Published: (2025-01-01)

Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma
by: Wenjing Liao, et al.
Published: (2025-01-01)