MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses
Abstract The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an i...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553689685262336 |
|---|---|
| author | Yupei Zhang Songhui Zhai Shugang Qin Yuting Chen Kepan Chen Zhiying Huang Xing Lan Yaoyao Luo Guohong Li Hao Li Xi He Meiwan Chen Zhongwei Zhang Xingchen Peng Xin Jiang Hai Huang Xiangrong Song |
| author_facet | Yupei Zhang Songhui Zhai Shugang Qin Yuting Chen Kepan Chen Zhiying Huang Xing Lan Yaoyao Luo Guohong Li Hao Li Xi He Meiwan Chen Zhongwei Zhang Xingchen Peng Xin Jiang Hai Huang Xiangrong Song |
| author_sort | Yupei Zhang |
| collection | DOAJ |
| description | Abstract The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines. This approach involved the integration of MITD into the mRNA sequence encoding the virus antigen. Mechanistically, MITD‐based mRNA vaccines can strengthen immune protection by mimicking the dynamic trafficking properties of MHCI molecule and thus expand the memory specific B and T cells. The model MITD‐based mRNA vaccines encoding binding receptor‐binding domain (RBD) of SARS‐CoV‐2 were indeed found to achieve protective duration, optimal storage stability, broad efficacy, and high safety. |
| format | Article |
| id | doaj-art-adaae9dfab384b87b25d68b020ece943 |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-adaae9dfab384b87b25d68b020ece9432025-01-09T06:19:46ZengWileyBioengineering & Translational Medicine2380-67612025-01-01101n/an/a10.1002/btm2.10709MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA virusesYupei Zhang0Songhui Zhai1Shugang Qin2Yuting Chen3Kepan Chen4Zhiying Huang5Xing Lan6Yaoyao Luo7Guohong Li8Hao Li9Xi He10Meiwan Chen11Zhongwei Zhang12Xingchen Peng13Xin Jiang14Hai Huang15Xiangrong Song16Department of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaDepartment of Critical Care Medicine Frontiers Science Center for Disease‐related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu Sichuan ChinaAbstract The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines. This approach involved the integration of MITD into the mRNA sequence encoding the virus antigen. Mechanistically, MITD‐based mRNA vaccines can strengthen immune protection by mimicking the dynamic trafficking properties of MHCI molecule and thus expand the memory specific B and T cells. The model MITD‐based mRNA vaccines encoding binding receptor‐binding domain (RBD) of SARS‐CoV‐2 were indeed found to achieve protective duration, optimal storage stability, broad efficacy, and high safety.https://doi.org/10.1002/btm2.10709frameworkimmune protectionMITDmRNA vaccinesRNA virus |
| spellingShingle | Yupei Zhang Songhui Zhai Shugang Qin Yuting Chen Kepan Chen Zhiying Huang Xing Lan Yaoyao Luo Guohong Li Hao Li Xi He Meiwan Chen Zhongwei Zhang Xingchen Peng Xin Jiang Hai Huang Xiangrong Song MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses Bioengineering & Translational Medicine framework immune protection MITD mRNA vaccines RNA virus |
| title | MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses |
| title_full | MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses |
| title_fullStr | MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses |
| title_full_unstemmed | MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses |
| title_short | MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses |
| title_sort | mhci trafficking signal based mrna vaccines strengthening immune protection against rna viruses |
| topic | framework immune protection MITD mRNA vaccines RNA virus |
| url | https://doi.org/10.1002/btm2.10709 |
| work_keys_str_mv | AT yupeizhang mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT songhuizhai mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT shugangqin mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT yutingchen mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT kepanchen mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT zhiyinghuang mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT xinglan mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT yaoyaoluo mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT guohongli mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT haoli mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT xihe mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT meiwanchen mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT zhongweizhang mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT xingchenpeng mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT xinjiang mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT haihuang mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses AT xiangrongsong mhcitraffickingsignalbasedmrnavaccinesstrengtheningimmuneprotectionagainstrnaviruses |