Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine
Abstract Representative models of intestinal diseases are transforming our knowledge of the molecular mechanisms of disease, facilitating effective drug screening and avenues for personalised medicine. Despite the emergence of 3D in vitro intestinal organoid culture systems that replicate the geneti...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-024-02092-9 |
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| author | Diana Micati Sara Hlavca Wing Hei Chan Helen E. Abud |
| author_facet | Diana Micati Sara Hlavca Wing Hei Chan Helen E. Abud |
| author_sort | Diana Micati |
| collection | DOAJ |
| description | Abstract Representative models of intestinal diseases are transforming our knowledge of the molecular mechanisms of disease, facilitating effective drug screening and avenues for personalised medicine. Despite the emergence of 3D in vitro intestinal organoid culture systems that replicate the genetic and functional characteristics of the epithelial tissue of origin, there are still challenges in reproducing the human physiological tissue environment in a format that enables functional readouts. Here, we describe the latest platforms engineered to investigate environmental tissue impacts, host-microbe interactions and enable drug discovery. This highlights the potential to revolutionise knowledge on the impact of intestinal infection and inflammation and enable personalised disease modelling and clinical translation. |
| format | Article |
| id | doaj-art-ad997215f2fd48f5a78fa6fc4e8c5b98 |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-ad997215f2fd48f5a78fa6fc4e8c5b982025-01-05T12:46:15ZengBMCBMC Biology1741-70072024-12-0122111410.1186/s12915-024-02092-9Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestineDiana Micati0Sara Hlavca1Wing Hei Chan2Helen E. Abud3Department of Anatomy and Developmental Biology, Monash UniversityDepartment of Anatomy and Developmental Biology, Monash UniversityDepartment of Anatomy and Developmental Biology, Monash UniversityDepartment of Anatomy and Developmental Biology, Monash UniversityAbstract Representative models of intestinal diseases are transforming our knowledge of the molecular mechanisms of disease, facilitating effective drug screening and avenues for personalised medicine. Despite the emergence of 3D in vitro intestinal organoid culture systems that replicate the genetic and functional characteristics of the epithelial tissue of origin, there are still challenges in reproducing the human physiological tissue environment in a format that enables functional readouts. Here, we describe the latest platforms engineered to investigate environmental tissue impacts, host-microbe interactions and enable drug discovery. This highlights the potential to revolutionise knowledge on the impact of intestinal infection and inflammation and enable personalised disease modelling and clinical translation.https://doi.org/10.1186/s12915-024-02092-9Intestinal diseasesInflammatory bowel diseaseModellingOrganoid co-cultureEpithelium-mesenchyme interactionEpithelial-microbe interaction |
| spellingShingle | Diana Micati Sara Hlavca Wing Hei Chan Helen E. Abud Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine BMC Biology Intestinal diseases Inflammatory bowel disease Modelling Organoid co-culture Epithelium-mesenchyme interaction Epithelial-microbe interaction |
| title | Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| title_full | Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| title_fullStr | Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| title_full_unstemmed | Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| title_short | Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| title_sort | harnessing 3d models to uncover the mechanisms driving infectious and inflammatory disease in the intestine |
| topic | Intestinal diseases Inflammatory bowel disease Modelling Organoid co-culture Epithelium-mesenchyme interaction Epithelial-microbe interaction |
| url | https://doi.org/10.1186/s12915-024-02092-9 |
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