Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees
The widespread and excessive agricultural use of azole fungicide tebuconazole poses a major threat to pollinator species including honey bee colonies as highlighted by recent studies. This issue is of growing importance, due to the intensification of modern agriculture and the increasing amount of t...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024173227 |
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| author | Máté Mackei Fanni Huber Csilla Sebők Júlia Vörösházi Patrik Tráj Rege Anna Márton Zsuzsanna Neogrády Gábor Mátis |
| author_facet | Máté Mackei Fanni Huber Csilla Sebők Júlia Vörösházi Patrik Tráj Rege Anna Márton Zsuzsanna Neogrády Gábor Mátis |
| author_sort | Máté Mackei |
| collection | DOAJ |
| description | The widespread and excessive agricultural use of azole fungicide tebuconazole poses a major threat to pollinator species including honey bee colonies as highlighted by recent studies. This issue is of growing importance, due to the intensification of modern agriculture and the increasing amount of the applied chemicals, serving as a major and recent problem from both an ecotoxicological and an agricultural point of view. The present study aims to detect the effects of acute sublethal tebuconazole exposure focusing on the redox homeostasis of honey bee flight muscles. The results show that the redox homeostasis, especially the glutathione system, of the exposed animals is severely impaired by the treatment, but flight muscles are able to successfully counteract the detrimental effects by the effective activation of protective processes. This efficient adaptation may have led to overcompensation processes eventually resulting in lower hydrogen peroxide and malondialdehyde concentrations after exposure. It could also be assumed that tebuconazole has a non-monotonic dose-response curve similarly to many other substances with endocrine-disrupting activity concerning parameters such as superoxide dismutase activity or total antioxidant capacity. These findings shed light on the detrimental impact of tebuconazole on the redox balance of honey bee flight muscles, also highlighting, that unlike other organs such as the brain, they may effectively adapt to acute tebuconazole exposure. |
| format | Article |
| id | doaj-art-ad95d638e9fc456a9a1ed7c3f182e01e |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ad95d638e9fc456a9a1ed7c3f182e01e2025-01-17T04:50:48ZengElsevierHeliyon2405-84402025-01-01111e41291Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey beesMáté Mackei0Fanni Huber1Csilla Sebők2Júlia Vörösházi3Patrik Tráj4Rege Anna Márton5Zsuzsanna Neogrády6Gábor Mátis7Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, Hungary; National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine Budapest, István Street 2, H-1078, Hungary; Corresponding author. Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, Hungary.Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, Hungary; National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine Budapest, István Street 2, H-1078, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, HungaryDivision of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, Hungary; National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine Budapest, István Street 2, H-1078, HungaryThe widespread and excessive agricultural use of azole fungicide tebuconazole poses a major threat to pollinator species including honey bee colonies as highlighted by recent studies. This issue is of growing importance, due to the intensification of modern agriculture and the increasing amount of the applied chemicals, serving as a major and recent problem from both an ecotoxicological and an agricultural point of view. The present study aims to detect the effects of acute sublethal tebuconazole exposure focusing on the redox homeostasis of honey bee flight muscles. The results show that the redox homeostasis, especially the glutathione system, of the exposed animals is severely impaired by the treatment, but flight muscles are able to successfully counteract the detrimental effects by the effective activation of protective processes. This efficient adaptation may have led to overcompensation processes eventually resulting in lower hydrogen peroxide and malondialdehyde concentrations after exposure. It could also be assumed that tebuconazole has a non-monotonic dose-response curve similarly to many other substances with endocrine-disrupting activity concerning parameters such as superoxide dismutase activity or total antioxidant capacity. These findings shed light on the detrimental impact of tebuconazole on the redox balance of honey bee flight muscles, also highlighting, that unlike other organs such as the brain, they may effectively adapt to acute tebuconazole exposure.http://www.sciencedirect.com/science/article/pii/S2405844024173227PesticideFungicideAzolesRedoxGlutathioneApis mellifera |
| spellingShingle | Máté Mackei Fanni Huber Csilla Sebők Júlia Vörösházi Patrik Tráj Rege Anna Márton Zsuzsanna Neogrády Gábor Mátis Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees Heliyon Pesticide Fungicide Azoles Redox Glutathione Apis mellifera |
| title | Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees |
| title_full | Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees |
| title_fullStr | Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees |
| title_full_unstemmed | Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees |
| title_short | Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees |
| title_sort | effective adaptation of flight muscles to tebuconazole induced oxidative stress in honey bees |
| topic | Pesticide Fungicide Azoles Redox Glutathione Apis mellifera |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024173227 |
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