CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

Abstract Genetic backgrounds of patients with pulmonary arterial hypertension (PAH) were not fully investigated. A variant of c.14429G > A (p.Arg4810Lys) in the ring finger protein 213 gene (RNF213) was recently identified as a risk allele for poor treatment response and poor clinical prognosis i...

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Main Authors: Takahiro Hiraide, Noboru Tsuda, Mizuki Momoi, Yoshiki Shinya, Motoaki Sano, Keiichi Fukuda, Junji Shibahara, Junko Kuramoto, Yae Kanai, Kenjiro Kosaki, Yoji Hakamata, Masaharu Kataoka
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-77388-5
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