Functional Dynamics of Arginine Mono- and Di-Methylation
Arginine methylation is a crucial post-translational modification (PTM) that plays a significant role in various biological processes. It occurs in two primary forms: mono-methylation (MMA) and di-methylation (DMA), with the latter further classified into symmetric (SDMA) and asymmetric methylation...
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MDPI AG
2025-05-01
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| author | Xi’ang Wang Bin Zhu Robert Winn Shanfa Lu Hengbin Wang |
| author_facet | Xi’ang Wang Bin Zhu Robert Winn Shanfa Lu Hengbin Wang |
| author_sort | Xi’ang Wang |
| collection | DOAJ |
| description | Arginine methylation is a crucial post-translational modification (PTM) that plays a significant role in various biological processes. It occurs in two primary forms: mono-methylation (MMA) and di-methylation (DMA), with the latter further classified into symmetric (SDMA) and asymmetric methylation (ADMA). This review examines the functional implications of these methylation states, current detection methodologies, proteomics-based analytical approaches, and the different impacts of these methylations on protein function. Finally, the role of protein arginine methyltransferases (PRMTs) and their substrate specificity in shaping the arginine methylome are discussed. |
| format | Article |
| id | doaj-art-ad75c213e33e435a81a6f2025c0241c8 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-ad75c213e33e435a81a6f2025c0241c82025-08-20T03:46:48ZengMDPI AGCells2073-44092025-05-01141179610.3390/cells14110796Functional Dynamics of Arginine Mono- and Di-MethylationXi’ang Wang0Bin Zhu1Robert Winn2Shanfa Lu3Hengbin Wang4Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Massey Comprehensive Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VI 23298, USADepartment of Internal Medicine, Division of Pulmonary Disease and Critical Care, Massey Comprehensive Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VI 23298, USADepartment of Internal Medicine, Division of Pulmonary Disease and Critical Care, Massey Comprehensive Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VI 23298, USAState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaDepartment of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Massey Comprehensive Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VI 23298, USAArginine methylation is a crucial post-translational modification (PTM) that plays a significant role in various biological processes. It occurs in two primary forms: mono-methylation (MMA) and di-methylation (DMA), with the latter further classified into symmetric (SDMA) and asymmetric methylation (ADMA). This review examines the functional implications of these methylation states, current detection methodologies, proteomics-based analytical approaches, and the different impacts of these methylations on protein function. Finally, the role of protein arginine methyltransferases (PRMTs) and their substrate specificity in shaping the arginine methylome are discussed.https://www.mdpi.com/2073-4409/14/11/796methylationarginine methylationdi-methylationmono-methylationPRMTs |
| spellingShingle | Xi’ang Wang Bin Zhu Robert Winn Shanfa Lu Hengbin Wang Functional Dynamics of Arginine Mono- and Di-Methylation Cells methylation arginine methylation di-methylation mono-methylation PRMTs |
| title | Functional Dynamics of Arginine Mono- and Di-Methylation |
| title_full | Functional Dynamics of Arginine Mono- and Di-Methylation |
| title_fullStr | Functional Dynamics of Arginine Mono- and Di-Methylation |
| title_full_unstemmed | Functional Dynamics of Arginine Mono- and Di-Methylation |
| title_short | Functional Dynamics of Arginine Mono- and Di-Methylation |
| title_sort | functional dynamics of arginine mono and di methylation |
| topic | methylation arginine methylation di-methylation mono-methylation PRMTs |
| url | https://www.mdpi.com/2073-4409/14/11/796 |
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