Retrospective analysis of CD4 count trends in South Africa
Background: South Africa has the largest HIV epidemic globally. Despite the scale-up of antiretroviral therapy, people living with HIV are still presenting with low CD4 counts. Objectives: This study assessed CD4 trends. Method: A retrospective analysis of laboratory data from 2013 to 2023 was con...
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| Format: | Article |
| Language: | English |
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AOSIS
2024-12-01
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| Series: | Southern African Journal of HIV Medicine |
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| Online Access: | https://sajhivmed.org.za/index.php/hivmed/article/view/1651 |
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| author | Naseem Cassim Lindi-Marie Coetzee Manuel P. Da Silva Deborah K. Glencross Wendy S. Stevens |
| author_facet | Naseem Cassim Lindi-Marie Coetzee Manuel P. Da Silva Deborah K. Glencross Wendy S. Stevens |
| author_sort | Naseem Cassim |
| collection | DOAJ |
| description | Background: South Africa has the largest HIV epidemic globally. Despite the scale-up of antiretroviral therapy, people living with HIV are still presenting with low CD4 counts.
Objectives: This study assessed CD4 trends.
Method: A retrospective analysis of laboratory data from 2013 to 2023 was conducted. Annual test volumes, the median CD4, and the percentage of specimens with a count ≤ 200 cells/μL and 500 cells/μL were reported at the national and provincial levels, and by age and gender. The percentage change in both CD4 categories between 2013 and 2023 was assessed, and the CD4 counts per 100 000 population reported.
Results: Data are reported for 32 154 644 specimens. The overall median CD4 increased from 396 cells/μL to 473 cells/μL. The percentage of specimens with CD4 counts 500 cells/μL increased over time but the percentage with CD4 counts ≤ 200 cells/μL remained stable. Men had lower CD4 median and higher percentage of specimens with counts ≤ 200 cells/μL than women. However, the rate of, CD4 ≤ 200 cells/μL decreased from 1411 to 700 per 100 000 population; this decrease occurred in all provinces except the Western Cape.
Conclusion: This study found high percentage of specimens with CD4 counts ≤ 200 cells/μL despite an increase in median CD4 count. Men had lower CD4 counts than women. |
| format | Article |
| id | doaj-art-ad531e400210434094d5ed84a8f60ccb |
| institution | Kabale University |
| issn | 1608-9693 2078-6751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of HIV Medicine |
| spelling | doaj-art-ad531e400210434094d5ed84a8f60ccb2025-01-14T12:14:04ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512024-12-01251e1e810.4102/sajhivmed.v25i1.1651881Retrospective analysis of CD4 count trends in South AfricaNaseem Cassim0Lindi-Marie Coetzee1Manuel P. Da Silva2Deborah K. Glencross3Wendy S. Stevens4Wits Diagnostic Innovation Hub, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and National Priority Programme, National Health Laboratory Service, JohannesburgWits Diagnostic Innovation Hub, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and National Priority Programme, National Health Laboratory Service, JohannesburgWits Diagnostic Innovation Hub, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and National Priority Programme, National Health Laboratory Service, JohannesburgFaculty of Health Sciences, University of the Witwatersrand, JohannesburgWits Diagnostic Innovation Hub, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and National Priority Programme, National Health Laboratory Service, JohannesburgBackground: South Africa has the largest HIV epidemic globally. Despite the scale-up of antiretroviral therapy, people living with HIV are still presenting with low CD4 counts. Objectives: This study assessed CD4 trends. Method: A retrospective analysis of laboratory data from 2013 to 2023 was conducted. Annual test volumes, the median CD4, and the percentage of specimens with a count ≤ 200 cells/μL and 500 cells/μL were reported at the national and provincial levels, and by age and gender. The percentage change in both CD4 categories between 2013 and 2023 was assessed, and the CD4 counts per 100 000 population reported. Results: Data are reported for 32 154 644 specimens. The overall median CD4 increased from 396 cells/μL to 473 cells/μL. The percentage of specimens with CD4 counts 500 cells/μL increased over time but the percentage with CD4 counts ≤ 200 cells/μL remained stable. Men had lower CD4 median and higher percentage of specimens with counts ≤ 200 cells/μL than women. However, the rate of, CD4 ≤ 200 cells/μL decreased from 1411 to 700 per 100 000 population; this decrease occurred in all provinces except the Western Cape. Conclusion: This study found high percentage of specimens with CD4 counts ≤ 200 cells/μL despite an increase in median CD4 count. Men had lower CD4 counts than women.https://sajhivmed.org.za/index.php/hivmed/article/view/1651hivcd4advanced hiv diseaselaboratory datadata repository |
| spellingShingle | Naseem Cassim Lindi-Marie Coetzee Manuel P. Da Silva Deborah K. Glencross Wendy S. Stevens Retrospective analysis of CD4 count trends in South Africa Southern African Journal of HIV Medicine hiv cd4 advanced hiv disease laboratory data data repository |
| title | Retrospective analysis of CD4 count trends in South Africa |
| title_full | Retrospective analysis of CD4 count trends in South Africa |
| title_fullStr | Retrospective analysis of CD4 count trends in South Africa |
| title_full_unstemmed | Retrospective analysis of CD4 count trends in South Africa |
| title_short | Retrospective analysis of CD4 count trends in South Africa |
| title_sort | retrospective analysis of cd4 count trends in south africa |
| topic | hiv cd4 advanced hiv disease laboratory data data repository |
| url | https://sajhivmed.org.za/index.php/hivmed/article/view/1651 |
| work_keys_str_mv | AT naseemcassim retrospectiveanalysisofcd4counttrendsinsouthafrica AT lindimariecoetzee retrospectiveanalysisofcd4counttrendsinsouthafrica AT manuelpdasilva retrospectiveanalysisofcd4counttrendsinsouthafrica AT deborahkglencross retrospectiveanalysisofcd4counttrendsinsouthafrica AT wendysstevens retrospectiveanalysisofcd4counttrendsinsouthafrica |