Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication
Abstract In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellu...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-024-02183-9 |
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| _version_ | 1846148054761078784 |
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| author | Hua Wang Tao Wang Shuxiang Yan Jinxin Tang Yibo Zhang Liming Wang Haodong Xu Chao Tu |
| author_facet | Hua Wang Tao Wang Shuxiang Yan Jinxin Tang Yibo Zhang Liming Wang Haodong Xu Chao Tu |
| author_sort | Hua Wang |
| collection | DOAJ |
| description | Abstract In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellular constituents within the TME, including immune cells, cancer-associated fibroblasts, and cancer cells themselves. These cytokines facilitate intricate communication networks that significantly influence tumor initiation, progression, metastasis, and immune suppression. Pyroptosis contributes to TME remodeling by promoting the release of pro-inflammatory cytokines and sustaining chronic inflammation, impacting processes such as immune escape and angiogenesis. However, challenges remain due to the complex interplay among cytokines, pyroptosis, and the TME, along with the dual effects of pyroptosis on cancer progression and therapy-related complications like cytokine release syndrome. Unraveling these complexities could facilitate strategies that balance inflammatory responses while minimizing tissue damage during therapy. This review delves into the complex crosstalk between cytokines, pyroptosis, and the TME, elucidating their contribution to tumor progression and metastasis. By synthesizing emerging therapeutic targets and innovative technologies concerning TME, this review aims to provide novel insights that could enhance treatment outcomes for cancer patients. |
| format | Article |
| id | doaj-art-ad34a8c3945d48cfb7c464e89a09def5 |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-ad34a8c3945d48cfb7c464e89a09def52024-12-01T12:12:54ZengBMCMolecular Cancer1476-45982024-11-0123113710.1186/s12943-024-02183-9Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implicationHua Wang0Tao Wang1Shuxiang Yan2Jinxin Tang3Yibo Zhang4Liming Wang5Haodong Xu6Chao Tu7Department of Orthopaedics, The Second Xiangya Hospital of Central South UniversityDepartment of Orthopaedics, The Second Xiangya Hospital of Central South UniversityDepartment of Nephrology, The Second Xiangya Hospital of Central South UniversityDepartment of Orthopaedics, The Second Xiangya Hospital of Central South UniversityDepartment of Orthopaedics, The Second Xiangya Hospital of Central South UniversitySchool of Biomedical Sciences, Hunan UniversityDepartment of Orthopaedics, The Second Xiangya Hospital of Central South UniversityDepartment of Orthopaedics, The Second Xiangya Hospital of Central South UniversityAbstract In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellular constituents within the TME, including immune cells, cancer-associated fibroblasts, and cancer cells themselves. These cytokines facilitate intricate communication networks that significantly influence tumor initiation, progression, metastasis, and immune suppression. Pyroptosis contributes to TME remodeling by promoting the release of pro-inflammatory cytokines and sustaining chronic inflammation, impacting processes such as immune escape and angiogenesis. However, challenges remain due to the complex interplay among cytokines, pyroptosis, and the TME, along with the dual effects of pyroptosis on cancer progression and therapy-related complications like cytokine release syndrome. Unraveling these complexities could facilitate strategies that balance inflammatory responses while minimizing tissue damage during therapy. This review delves into the complex crosstalk between cytokines, pyroptosis, and the TME, elucidating their contribution to tumor progression and metastasis. By synthesizing emerging therapeutic targets and innovative technologies concerning TME, this review aims to provide novel insights that could enhance treatment outcomes for cancer patients.https://doi.org/10.1186/s12943-024-02183-9PyroptosisCytokineTumor microenvironmentMechanismClinical implication |
| spellingShingle | Hua Wang Tao Wang Shuxiang Yan Jinxin Tang Yibo Zhang Liming Wang Haodong Xu Chao Tu Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication Molecular Cancer Pyroptosis Cytokine Tumor microenvironment Mechanism Clinical implication |
| title | Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication |
| title_full | Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication |
| title_fullStr | Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication |
| title_full_unstemmed | Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication |
| title_short | Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication |
| title_sort | crosstalk of pyroptosis and cytokine in the tumor microenvironment from mechanisms to clinical implication |
| topic | Pyroptosis Cytokine Tumor microenvironment Mechanism Clinical implication |
| url | https://doi.org/10.1186/s12943-024-02183-9 |
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