Astilbin improves the therapeutic effects of mesenchymal stem cells in AKI-CKD mice by regulating macrophage polarization through PTGS2-mediated pathway

Astilbin improves the therapeutic effects of mesenchymal stem cells in AKI-CKD mice by regulating macrophage polarization through PTGS2-mediated pathway

Abstract Background Although mesenchymal stem cells (MSCs) have been proven to be appropriate candidates for the treatment of AKI-CKD, their efficacy is limited and variable. Astilbin (AST) had a protective effect on MSCs from oxidative stress via ROS-scavenging, however, whether it can improve MSCs...

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Bibliographic Details
Main Authors: Xiaodong Geng, Zhangning Fu, Guangrui Geng, Kun Chi, Chao Liu, Haijuan Hong, Guangyan Cai, Xiangmei Chen, Quan Hong
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Astilbin
Mesenchymal stem cells
Macrophage polarization
AKI-CKD
PGE2
Online Access:https://doi.org/10.1186/s13287-024-04025-3
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