Adverse Effects of Aβ<sub>1-42</sub> Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons

Adverse Effects of Aβ<sub>1-42</sub> Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons

Aβ<sub>1-42</sub> (amyloid beta) oligomers, the major neurotoxic culprits in Alzheimer’s disease, initiate early pathophysiological events, including neuronal hyperactivity, that underlie aberrant network activity and cognitive impairment. Although several synaptotoxic effects have been...

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Bibliographic Details
Main Authors: Min-Kaung-Wint-Mon, Hiroyuki Kida, Itsuki Kanehisa, Masahiko Kurose, Junko Ishikawa, Yuya Sakimoto, Paw-Min-Thein-Oo, Ryoichi Kimura, Dai Mitsushima
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
Aβ<sub>1-42</sub> oligomers
contextual memory
intrinsic properties
neuronal hyperexcitability
riluzole
lecanemab
Online Access:https://www.mdpi.com/2218-273X/14/11/1425
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