(4a<i>S</i>,5S,6a<i>R</i>,10a<i>R</i>,10b<i>R</i>)-5-Methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12<i>H</i>-[1,3]dioxino[4′,5′:5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-d][1,4]oxazine

(4a<i>S</i>,5S,6a<i>R</i>,10a<i>R</i>,10b<i>R</i>)-5-Methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12<i>H</i>-[1,3]dioxino[4′,5′:5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-d][1,4]oxazine

A new tetracyclic morpholine-fused[5,1-<i>c</i>]-triazole, (4a<i>S</i>,5S,6a<i>R</i>,10a<i>R</i>,10b<i>R</i>)-5-methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12<i>H</i>-[1,3]dioxino[4′,5′:5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-...

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Bibliographic Details
Main Authors:	Leticia Lomas Romero, Guillermo E. Negron Silva, Ricardo Corona-Sánchez, Elsie Ramírez-Domínguez, Atilano Gutiérrez-Carrillo, Alma Sánchez-Eleuterio
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Series:	Molbank
Subjects:	1,2,3-triazoles click chemistry carbohydrates morpholine-fused[5,1-<i>c</i>]-triazole
Online Access:	https://www.mdpi.com/1422-8599/2024/4/M1898
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Summary:	A new tetracyclic morpholine-fused[5,1-<i>c</i>]-triazole, (4a<i>S</i>,5S,6a<i>R</i>,10a<i>R</i>,10b<i>R</i>)-5-methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12<i>H</i>-[1,3]dioxino[4′,5′:5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-d][1,4]oxazine, was synthesized via a five-step sequence starting from methyl α-<sub>D</sub>-glucopyranoside by using, as a key step, an intramolecular copper(I) catalyzed alkyne-azide cycloaddition (CuAAC). The synthesized compound was fully characterized by <sup>1</sup>H and <sup>13</sup>C NMR, FT-IR, and HRMS.
ISSN:	1422-8599