The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy
Fyn is a cytoplasmic tyrosine kinase (TK) that is a nonreceptor and a member of the Src family of kinases (SFKs). It is involved in several transduction pathways in the central nervous system (CNS), such as oligodendrocyte development, myelination, axon guidance, and synaptic transmission. Owing to...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1476856/full |
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| author | Jiao Zhou Jiao Zhou Xiang Lu Haichuan Wang |
| author_facet | Jiao Zhou Jiao Zhou Xiang Lu Haichuan Wang |
| author_sort | Jiao Zhou |
| collection | DOAJ |
| description | Fyn is a cytoplasmic tyrosine kinase (TK) that is a nonreceptor and a member of the Src family of kinases (SFKs). It is involved in several transduction pathways in the central nervous system (CNS), such as oligodendrocyte development, myelination, axon guidance, and synaptic transmission. Owing to its wide range of activities in the molecular signaling pathways that underpin both neuropathologic and neurodevelopmental events, Fyn has remained of great interest for more than a century. Accumulating preclinical data have highlighted the potential role of Fyn in the pathophysiology of neonatal hypoxic-ischaemic encephalopathy (HIE). By mediating important signaling pathways, Fyn may control glutamate excitotoxicity, promote neuroinflammation and facilitate the death of neurons caused by oxidative stress. In this review, we address new evidence regarding the role of Fyn in the pathogenesis of this condition, with the aim of providing a reference for the development of new strategies to improve the prognosis of neonatal HIE. In addition, we also offer insights into additional Fyn-related molecular mechanisms involved in HIE pathology. |
| format | Article |
| id | doaj-art-ad08525fae814b4681c6f5c7f90d6ec0 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-ad08525fae814b4681c6f5c7f90d6ec02024-11-27T04:21:21ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-11-011810.3389/fncel.2024.14768561476856The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathyJiao Zhou0Jiao Zhou1Xiang Lu2Haichuan Wang3Department of Reproductive Medicine Nursing, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Cardiology, The First People’s Hospital of Yuexi County, Yuexi, ChinaDepartment of Paediatrics, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaFyn is a cytoplasmic tyrosine kinase (TK) that is a nonreceptor and a member of the Src family of kinases (SFKs). It is involved in several transduction pathways in the central nervous system (CNS), such as oligodendrocyte development, myelination, axon guidance, and synaptic transmission. Owing to its wide range of activities in the molecular signaling pathways that underpin both neuropathologic and neurodevelopmental events, Fyn has remained of great interest for more than a century. Accumulating preclinical data have highlighted the potential role of Fyn in the pathophysiology of neonatal hypoxic-ischaemic encephalopathy (HIE). By mediating important signaling pathways, Fyn may control glutamate excitotoxicity, promote neuroinflammation and facilitate the death of neurons caused by oxidative stress. In this review, we address new evidence regarding the role of Fyn in the pathogenesis of this condition, with the aim of providing a reference for the development of new strategies to improve the prognosis of neonatal HIE. In addition, we also offer insights into additional Fyn-related molecular mechanisms involved in HIE pathology.https://www.frontiersin.org/articles/10.3389/fncel.2024.1476856/fullFynHIEmolecular mechanismpathogenesisbrain |
| spellingShingle | Jiao Zhou Jiao Zhou Xiang Lu Haichuan Wang The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy Frontiers in Cellular Neuroscience Fyn HIE molecular mechanism pathogenesis brain |
| title | The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy |
| title_full | The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy |
| title_fullStr | The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy |
| title_full_unstemmed | The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy |
| title_short | The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy |
| title_sort | underlying molecular mechanisms of fyn in neonatal hypoxic ischaemic encephalopathy |
| topic | Fyn HIE molecular mechanism pathogenesis brain |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1476856/full |
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