Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
Medication-related osteonecrosis of the jaw is an adverse reaction caused by the use of antiresorptive antiangiogenic medication. The most commonly affected areas are posterior regions of mandible and maxilla. However, a simultaneous occurrence in both jaws is rarely observe...
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| Format: | Article |
| Language: | English |
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Ankara University
2024-08-01
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| Series: | European Annals of Dental Sciences |
| Online Access: | https://dergipark.org.tr/en/doi/10.52037/eads.2024.0009 |
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| _version_ | 1841525480084209664 |
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| author | Amisha Parekh Pedro Tretto Nicklaus Blue Blake Dunaway James Lott Michael Roach Rohan Jagtap |
| author_facet | Amisha Parekh Pedro Tretto Nicklaus Blue Blake Dunaway James Lott Michael Roach Rohan Jagtap |
| author_sort | Amisha Parekh |
| collection | DOAJ |
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Medication-related osteonecrosis of the jaw is an adverse reaction caused by the use of antiresorptive antiangiogenic medication. The most commonly affected areas are posterior regions of mandible and maxilla. However, a simultaneous occurrence in both jaws is rarely observed. We present an interesting case of MRONJ affecting both jaws. A 47-year old female presented with pain and swelling in the left posterior region of the mandible. The patient’s medical history was significant for breast cancer with ongoing bisphosphonate therapy. Cone-beam CT (CBCT) confirmed the presence of an extraction socket at the site of complaint. There was evidence of a diffuse sclerotic bone reaction in the maxillary posterior region bilaterally. The mandible showed presence of diffuse sclerotic bone only in the left para-symphysis and posterior region in addition to association with a periosteal bone reaction in the left para-symphysis region. Considering these findings and a history of exposure to bisphosphonate medication, the final diagnosis was conclusive of MRONJ. Management was aimed at suppressing the symptoms of pain and infection. The present case study reinforces the importance of correlating clinical and radiographic findings. Early diagnosis of MRONJ may lead to a more conservative treatment approach, greatly improving the patient’s prognosis.Keywords: MRONJ, Cone-beam CT, breast cancer, bisphosphonate |
| format | Article |
| id | doaj-art-ad024266592c482bb54ea1c26d67d876 |
| institution | Kabale University |
| issn | 2757-6744 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Ankara University |
| record_format | Article |
| series | European Annals of Dental Sciences |
| spelling | doaj-art-ad024266592c482bb54ea1c26d67d8762025-01-17T11:29:16ZengAnkara UniversityEuropean Annals of Dental Sciences2757-67442024-08-01512848810.52037/eads.2024.0009 Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature Amisha Parekh0https://orcid.org/0000-0002-3478-4806Pedro Tretto1https://orcid.org/0000-0002-9676-2338Nicklaus Blue2https://orcid.org/0009-0008-1523-1852Blake Dunaway3https://orcid.org/0009-0004-8639-4799James Lott4https://orcid.org/0009-0000-2538-1020Michael Roach5https://orcid.org/0000-0002-8250-4610Rohan Jagtap6https://orcid.org/0000-0002-9115-7235University of Mississippi Medical CenterRegional Integrated University of Alto Uruguai and Missões, Erechim, Brazil. School of Dentistry.University of Mississippi Medical CenterUniversity of Mississippi Medical CenterUniversity of Mississippi Medical CenterUniversity of Mississippi Medical CenterUniversity of Mississippi Medical Center School of Dentistry Medication-related osteonecrosis of the jaw is an adverse reaction caused by the use of antiresorptive antiangiogenic medication. The most commonly affected areas are posterior regions of mandible and maxilla. However, a simultaneous occurrence in both jaws is rarely observed. We present an interesting case of MRONJ affecting both jaws. A 47-year old female presented with pain and swelling in the left posterior region of the mandible. The patient’s medical history was significant for breast cancer with ongoing bisphosphonate therapy. Cone-beam CT (CBCT) confirmed the presence of an extraction socket at the site of complaint. There was evidence of a diffuse sclerotic bone reaction in the maxillary posterior region bilaterally. The mandible showed presence of diffuse sclerotic bone only in the left para-symphysis and posterior region in addition to association with a periosteal bone reaction in the left para-symphysis region. Considering these findings and a history of exposure to bisphosphonate medication, the final diagnosis was conclusive of MRONJ. Management was aimed at suppressing the symptoms of pain and infection. The present case study reinforces the importance of correlating clinical and radiographic findings. Early diagnosis of MRONJ may lead to a more conservative treatment approach, greatly improving the patient’s prognosis.Keywords: MRONJ, Cone-beam CT, breast cancer, bisphosphonatehttps://dergipark.org.tr/en/doi/10.52037/eads.2024.0009 |
| spellingShingle | Amisha Parekh Pedro Tretto Nicklaus Blue Blake Dunaway James Lott Michael Roach Rohan Jagtap Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature European Annals of Dental Sciences |
| title |
Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
|
| title_full |
Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
|
| title_fullStr |
Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
|
| title_full_unstemmed |
Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
|
| title_short |
Medication Related Osteonecrosis of the Jaw: A Case Report and Review of Literature
|
| title_sort | medication related osteonecrosis of the jaw a case report and review of literature |
| url | https://dergipark.org.tr/en/doi/10.52037/eads.2024.0009 |
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