A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy

A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy

Abstract Reports of secondary malignancies after chimeric antigen receptor (CAR)-T and possible CAR-T derived malignant transformation necessitate caution. Here we describe a patient with diffuse large B-cell lymphoma who developed new lymphadenopathy 2.5 years after CAR-T in the context of COVID-19...

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Main Authors: Katie Maurer, Jackson A. Weir, Adi Nagler, Nicholas J. Haradhvala, Hariharan Bharadwaj, Jacob Shapiro, Somkene Alakwe, Vipin Kumar, Brianna Waller, Mikaela McDonough, Jamie Dela Cruz, Loida Luna, Emma Lin, Linsey Gong, Qiyu Gong, Mehdi Borji, Phillip D. Michaels, Jacob P. Laubach, Geraldine Pinkus, Gad Getz, Catherine J. Wu, Fei Chen, Caron Jacobson
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62709-7
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