Preliminary study of the role of inner ear proteins in vestibular neuritis
Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN. Methods: In this preliminary study, 30 patients diagnosed with VN and 70 he...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-07-01
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| Series: | Journal of Otology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293024000217 |
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| _version_ | 1846139904315097088 |
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| author | Rong Wang Weiwei Han Li Li Lulu Li Xiaoxia Liu Yunqin Wu Weinv Fan |
| author_facet | Rong Wang Weiwei Han Li Li Lulu Li Xiaoxia Liu Yunqin Wu Weinv Fan |
| author_sort | Rong Wang |
| collection | DOAJ |
| description | Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN. Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared. Results: The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV. Conclusions: Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN. |
| format | Article |
| id | doaj-art-ac832f75b23444e5b76fb6b72064cbc6 |
| institution | Kabale University |
| issn | 1672-2930 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj-art-ac832f75b23444e5b76fb6b72064cbc62024-12-06T05:13:08ZengElsevierJournal of Otology1672-29302024-07-01193140143Preliminary study of the role of inner ear proteins in vestibular neuritisRong Wang0Weiwei Han1Li Li2Lulu Li3Xiaoxia Liu4Yunqin Wu5Weinv Fan6Department of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China; School of Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, PR ChinaDepartment of Rehabilitation, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR ChinaDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR ChinaDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR ChinaDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR ChinaDepartment of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China; Corresponding author. Department of Neurology, Ningbo No.2 Hospital, Ningbo, 315010, PR China.Department of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China; Corresponding author. Department of Neurology, Ningbo No.2 Hospital, Ningbo, 315010, PR China.Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN. Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared. Results: The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV. Conclusions: Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.http://www.sciencedirect.com/science/article/pii/S1672293024000217Vestibular neuritisInner ear proteinOtoconin-90Otolin-1 |
| spellingShingle | Rong Wang Weiwei Han Li Li Lulu Li Xiaoxia Liu Yunqin Wu Weinv Fan Preliminary study of the role of inner ear proteins in vestibular neuritis Journal of Otology Vestibular neuritis Inner ear protein Otoconin-90 Otolin-1 |
| title | Preliminary study of the role of inner ear proteins in vestibular neuritis |
| title_full | Preliminary study of the role of inner ear proteins in vestibular neuritis |
| title_fullStr | Preliminary study of the role of inner ear proteins in vestibular neuritis |
| title_full_unstemmed | Preliminary study of the role of inner ear proteins in vestibular neuritis |
| title_short | Preliminary study of the role of inner ear proteins in vestibular neuritis |
| title_sort | preliminary study of the role of inner ear proteins in vestibular neuritis |
| topic | Vestibular neuritis Inner ear protein Otoconin-90 Otolin-1 |
| url | http://www.sciencedirect.com/science/article/pii/S1672293024000217 |
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