A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9
ABSTRACT CRISPR Cas system is a revolutionary and precise genome editing system that induces bacterial and archaeal adaptive immunity and already has shown several promising applications in the treatment of genetic diseases and detection of nucleic acid targets. It is a complex tool, comprising dive...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Nano Select |
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| Online Access: | https://doi.org/10.1002/nano.202400009 |
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| author | Akram Hosen Md Nakibul Hasan Nishat MD. Mohaimin Hossain Soaib Omar Sharif Sharkar Md. Sahabuddin Imdadul Haque Sharif Sujay Kumar Bhajan |
| author_facet | Akram Hosen Md Nakibul Hasan Nishat MD. Mohaimin Hossain Soaib Omar Sharif Sharkar Md. Sahabuddin Imdadul Haque Sharif Sujay Kumar Bhajan |
| author_sort | Akram Hosen |
| collection | DOAJ |
| description | ABSTRACT CRISPR Cas system is a revolutionary and precise genome editing system that induces bacterial and archaeal adaptive immunity and already has shown several promising applications in the treatment of genetic diseases and detection of nucleic acid targets. It is a complex tool, comprising diverse effector proteins and guide RNA that can be applied to dissociate and modify genes in living organisms along with the in vitro process. The review concentrates on the advances accomplished from some recent years to 2023 for the emergence of predicting actions of Cas protein with the guide RNA (gRNA), playing a key role in genome editing. This review emphasizes the effect of DNA structure and chromosomal protein on Cas 9 binding with a distinct classification of Cas types. The relevance of this review is highlighted by the significance of the rapid development of wide study methods and their potential impacts on the efficiency of the CRISPR Cas system. We have analyzed recent kinds of literature in this work to integrate a deep learning way that contributes over the next time with some important discussion about viral resistance in eukaryotes along with some cancer treatment strategies, and crop improvement by the CRISPR Cas system. |
| format | Article |
| id | doaj-art-ac7eb28793eb405aa1953671e2fbebe7 |
| institution | Kabale University |
| issn | 2688-4011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj-art-ac7eb28793eb405aa1953671e2fbebe72025-01-09T03:49:58ZengWiley-VCHNano Select2688-40112025-01-0161n/an/a10.1002/nano.202400009A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9Akram Hosen0Md Nakibul Hasan Nishat1MD. Mohaimin Hossain Soaib2Omar Sharif Sharkar3Md. Sahabuddin4Imdadul Haque Sharif5Sujay Kumar Bhajan6Faculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Science Department of Physics Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshFaculty of Life Science Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj BangladeshABSTRACT CRISPR Cas system is a revolutionary and precise genome editing system that induces bacterial and archaeal adaptive immunity and already has shown several promising applications in the treatment of genetic diseases and detection of nucleic acid targets. It is a complex tool, comprising diverse effector proteins and guide RNA that can be applied to dissociate and modify genes in living organisms along with the in vitro process. The review concentrates on the advances accomplished from some recent years to 2023 for the emergence of predicting actions of Cas protein with the guide RNA (gRNA), playing a key role in genome editing. This review emphasizes the effect of DNA structure and chromosomal protein on Cas 9 binding with a distinct classification of Cas types. The relevance of this review is highlighted by the significance of the rapid development of wide study methods and their potential impacts on the efficiency of the CRISPR Cas system. We have analyzed recent kinds of literature in this work to integrate a deep learning way that contributes over the next time with some important discussion about viral resistance in eukaryotes along with some cancer treatment strategies, and crop improvement by the CRISPR Cas system.https://doi.org/10.1002/nano.202400009Cas proteins classesCRISPR Cas 9 MechanismsCRISPR Cas systemsCRISPR Case componentsCRISPR's contribution‐cancerscrop improvements |
| spellingShingle | Akram Hosen Md Nakibul Hasan Nishat MD. Mohaimin Hossain Soaib Omar Sharif Sharkar Md. Sahabuddin Imdadul Haque Sharif Sujay Kumar Bhajan A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 Nano Select Cas proteins classes CRISPR Cas 9 Mechanisms CRISPR Cas systems CRISPR Case components CRISPR's contribution‐cancers crop improvements |
| title | A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 |
| title_full | A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 |
| title_fullStr | A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 |
| title_full_unstemmed | A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 |
| title_short | A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9 |
| title_sort | review crispr cas system and the mechanism with an inhibition of binding of crispr cas 9 |
| topic | Cas proteins classes CRISPR Cas 9 Mechanisms CRISPR Cas systems CRISPR Case components CRISPR's contribution‐cancers crop improvements |
| url | https://doi.org/10.1002/nano.202400009 |
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