Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures

Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures

Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, comprises embryonal (ERMS) and alveolar (ARMS) subtypes with distinct histopathological features, clinical outcomes, and therapeutic responses. To better characterize their molecular distinctions, we performed untargeted plasma p...

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Bibliographic Details
Main Authors: Aya Osama, Ahmed Karam, Abdelrahman Atef, Menna Arafat, Rahma W. Afifi, Maha Mokhtar, Taghreed Khaled Abdelmoneim, Asmaa Ramzy, Enas El Nadi, Asmaa Salama, Emad Elzayat, Sameh Magdeldin
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
rhabdomyosarcoma
embryonal RMS (ERMS)
alveolar RMS (ARMS)
proteomics
metabolomics
multi-omics integration
Online Access:https://www.mdpi.com/2073-4409/14/14/1115
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