Ectopic ULBP2 Is Associated with Decreased NKG2D Expression in CD8<sup>+</sup> T Cells Under T Cell-Modulatory Conditions in a Murine Tumor Model

Ectopic ULBP2 Is Associated with Decreased NKG2D Expression in CD8<sup>+</sup> T Cells Under T Cell-Modulatory Conditions in a Murine Tumor Model

UL16-binding protein 2 (ULBP2), a ligand for the activating receptor NKG2D, plays a dual role in tumor immunity, promoting immune activation or suppression, depending on the context. To investigate its impact on CD4<sup>+</sup>CD25<sup>+</sup> T cell-targeted immunotherapies,...

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Bibliographic Details
Main Authors: Yasuhiko Teruya, Kosuke Yamaguchi, Kohei Yamane, Naomi Miyake, Yuji Nakayama, Takafumi Nonaka, Hiroki Chikumi, Akira Yamasaki
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
ULBP2
NKG2D ligands
NKG2D
tumor immunology
CD4<sup>+</sup> T cells
Treg
Online Access:https://www.mdpi.com/2073-4409/14/12/893
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