Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism
Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hopelessness, executive fu...
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2024-09-01
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| Series: | Annals of Geriatric Medicine and Research |
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| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-24-0037.pdf |
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| author | Ying Lin Chen Lin Jason Hong-Yi Chang Dai-Lun Chiang Feipei Lai Chen-Ju Lin |
| author_facet | Ying Lin Chen Lin Jason Hong-Yi Chang Dai-Lun Chiang Feipei Lai Chen-Ju Lin |
| author_sort | Ying Lin |
| collection | DOAJ |
| description | Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hopelessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm. |
| format | Article |
| id | doaj-art-ac1a642d16ab4eb28d31a5ffb37f2ca6 |
| institution | Kabale University |
| issn | 2508-4798 2508-4909 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj-art-ac1a642d16ab4eb28d31a5ffb37f2ca62024-11-19T00:12:42ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092024-09-0128337037410.4235/agmr.24.00371138Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic MechanismYing Lin0Chen Lin1Jason Hong-Yi Chang2Dai-Lun Chiang3Feipei Lai4Chen-Ju Lin5 Department of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan Department of Biomedical Sciences and Engineering, National Central University, Chunli, Taiwan Department of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan Financial Technology Applications Program, Ming Chuan University, Taoyuan, Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan Department of Psychiatry, MacKay Memorial Hospital, Taipei, TaiwanAlthough neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hopelessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm.http://www.e-agmr.org/upload/pdf/agmr-24-0037.pdfcovid-19covid brain fogagedpost-acute covid-19 syndromeallostasis |
| spellingShingle | Ying Lin Chen Lin Jason Hong-Yi Chang Dai-Lun Chiang Feipei Lai Chen-Ju Lin Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism Annals of Geriatric Medicine and Research covid-19 covid brain fog aged post-acute covid-19 syndrome allostasis |
| title | Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism |
| title_full | Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism |
| title_fullStr | Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism |
| title_full_unstemmed | Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism |
| title_short | Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism |
| title_sort | psychomotor symptoms cognitive impairments and suicidal thoughts after covid 19 infection a case report and possible allostatic mechanism |
| topic | covid-19 covid brain fog aged post-acute covid-19 syndrome allostasis |
| url | http://www.e-agmr.org/upload/pdf/agmr-24-0037.pdf |
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