Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study
Insulin resistance has been proposed as a contributing factor to major depressive disorder (MDD), with previous studies reporting a positive correlation between triglyceride-glucose (TyG) a proxy indicator of insulin resistance and MDD. However, limited information is available regarding their long...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11800 |
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| author | Zhang-Yang Xu Hong Zheng Zi-Jun Pan Shou-Yi Hu Yun-Xia Wang Wen-Jun Su |
| author_facet | Zhang-Yang Xu Hong Zheng Zi-Jun Pan Shou-Yi Hu Yun-Xia Wang Wen-Jun Su |
| author_sort | Zhang-Yang Xu |
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Insulin resistance has been proposed as a contributing factor to major depressive disorder (MDD), with previous studies reporting a positive correlation between triglyceride-glucose (TyG) a proxy indicator of insulin resistance and MDD. However, limited information is available regarding their longitudinal association. This study aimed to clarify the connection between TyG levels and depression risk, as well as explore its predictive potential. A total of 3,021 participants without a prior history of depression were recruited from the China Health and Retirement Longitudinal Study (CHARLS) and followed for seven years. Participants were categorized into tertiles based on their TyG levels. The cumulative hazard of depression was analyzed using Kaplan-Meier curves, while Cox regression analyses and multivariable-adjusted restricted cubic spline (RCS) curves were employed to assess the relationship between TyG levels and depression risk. Stratified analyses across various subgroups were also conducted to confirm the robustness of the conclusions.Over the follow-up period, 1,782 participants (58.9%) developed depression, with incidence rates of 30.2%, 34.0%, and 35.8% in tertiles 1, 2, and 3, respectively. After adjusting for confounding factors, each 1-unit increase in TyG was associated with a significantly higher risk of depression. RCS curve analysis revealed a compelling dose-response relationship between TyG levels and depression susceptibility. These findings indicate that elevated TyG levels are strongly associated with an increased risk of depression and could serve as a reliable biomarker for assessing depression risk. These insights provide valuable guidance for developing more effective strategies for the prevention and treatment of depressive disorders.
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| format | Article |
| id | doaj-art-abc804d030334ed9bf47686b996adc71 |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| series | Biomolecules & Biomedicine |
| spelling | doaj-art-abc804d030334ed9bf47686b996adc712025-01-16T16:40:11ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-01-0110.17305/bb.2024.11800Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort studyZhang-Yang Xu0https://orcid.org/0000-0003-3352-5324Hong Zheng1Zi-Jun Pan2Shou-Yi Hu3Yun-Xia Wang4Wen-Jun Su5https://orcid.org/0000-0002-2707-3600Department of Stress Medicine, Faculty of Psychology, Second Military Medical University, Shanghai, China; Department of Nautical Psychology, Faculty of Psychology, Second Military Medical University, Shanghai, ChinaDepartment of Stress Medicine, Faculty of Psychology, Second Military Medical University, Shanghai, ChinaDepartment of Medical Psychology, Changzheng Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, ChinaDepartment of Nautical Psychology, Faculty of Psychology, Second Military Medical University, Shanghai, ChinaDepartment of Stress Medicine, Faculty of Psychology, Second Military Medical University, Shanghai, China Insulin resistance has been proposed as a contributing factor to major depressive disorder (MDD), with previous studies reporting a positive correlation between triglyceride-glucose (TyG) a proxy indicator of insulin resistance and MDD. However, limited information is available regarding their longitudinal association. This study aimed to clarify the connection between TyG levels and depression risk, as well as explore its predictive potential. A total of 3,021 participants without a prior history of depression were recruited from the China Health and Retirement Longitudinal Study (CHARLS) and followed for seven years. Participants were categorized into tertiles based on their TyG levels. The cumulative hazard of depression was analyzed using Kaplan-Meier curves, while Cox regression analyses and multivariable-adjusted restricted cubic spline (RCS) curves were employed to assess the relationship between TyG levels and depression risk. Stratified analyses across various subgroups were also conducted to confirm the robustness of the conclusions.Over the follow-up period, 1,782 participants (58.9%) developed depression, with incidence rates of 30.2%, 34.0%, and 35.8% in tertiles 1, 2, and 3, respectively. After adjusting for confounding factors, each 1-unit increase in TyG was associated with a significantly higher risk of depression. RCS curve analysis revealed a compelling dose-response relationship between TyG levels and depression susceptibility. These findings indicate that elevated TyG levels are strongly associated with an increased risk of depression and could serve as a reliable biomarker for assessing depression risk. These insights provide valuable guidance for developing more effective strategies for the prevention and treatment of depressive disorders. https://www.bjbms.org/ojs/index.php/bjbms/article/view/11800Depressiontriglyceride-glucose indexTyG indexcox regression modellongitudinal studybiomarker |
| spellingShingle | Zhang-Yang Xu Hong Zheng Zi-Jun Pan Shou-Yi Hu Yun-Xia Wang Wen-Jun Su Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study Biomolecules & Biomedicine Depression triglyceride-glucose index TyG index cox regression model longitudinal study biomarker |
| title | Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study |
| title_full | Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study |
| title_fullStr | Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study |
| title_full_unstemmed | Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study |
| title_short | Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study |
| title_sort | association between triglyceride glucose tyg index and risk of depression in middle aged and elderly chinese adults evidence from a large national cohort study |
| topic | Depression triglyceride-glucose index TyG index cox regression model longitudinal study biomarker |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11800 |
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