Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations
BackgroundLung cancer, the primary cause of cancer-related deaths, often metastasizes early, commonly affecting the liver, brain, bones, and adrenal glands. Although gastrointestinal (GI) metastasis is rare, it poses significant diagnostic and therapeutic challenges and is frequently linked to sever...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1486371/full |
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| author | Xinxin Xu Qian Zhou Qian Zhou Peng Chen Chengzhou Du Yonghua Huang Xiaoxin Gao Shumei Xu Jinling Wu Tianxiao He Hongtao Li |
| author_facet | Xinxin Xu Qian Zhou Qian Zhou Peng Chen Chengzhou Du Yonghua Huang Xiaoxin Gao Shumei Xu Jinling Wu Tianxiao He Hongtao Li |
| author_sort | Xinxin Xu |
| collection | DOAJ |
| description | BackgroundLung cancer, the primary cause of cancer-related deaths, often metastasizes early, commonly affecting the liver, brain, bones, and adrenal glands. Although gastrointestinal (GI) metastasis is rare, it poses significant diagnostic and therapeutic challenges and is frequently linked to severe complications.Case descriptionWe present a case of a 61-year-old male with a history of lung cancer who presented with intestinal obstruction. The initial diagnosis of poorly differentiated adenocarcinoma was confirmed by computed tomography (CT) and bronchoscopic biopsy. The patient underwent chemotherapy, after which he developed intestinal obstruction. Further imaging and histopathological analysis indicated GI metastasis. Despite treatment with both chemotherapy and immunotherapy, the patient experienced recurrent obstruction, necessitating surgical intervention. Postoperatively, he had another episode of perforation, which was addressed with an emergency laparotomy, revealing metastatic adenocarcinoma at the site of perforation.ConclusionsThis case highlights the complexities in diagnosing and treating GI metastases from lung cancer. It underscores the necessity for multimodal treatment strategies and underscores the urgent need for research focused on early detection methods to improve patient outcomes. |
| format | Article |
| id | doaj-art-aba04451e9eb4a50b0d5aa67bb4db8a3 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-aba04451e9eb4a50b0d5aa67bb4db8a32024-11-26T05:10:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14863711486371Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovationsXinxin Xu0Qian Zhou1Qian Zhou2Peng Chen3Chengzhou Du4Yonghua Huang5Xiaoxin Gao6Shumei Xu7Jinling Wu8Tianxiao He9Hongtao Li10Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The Second Clinical Medical School of Lanzhou University, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of Radiology, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaDepartment of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaBackgroundLung cancer, the primary cause of cancer-related deaths, often metastasizes early, commonly affecting the liver, brain, bones, and adrenal glands. Although gastrointestinal (GI) metastasis is rare, it poses significant diagnostic and therapeutic challenges and is frequently linked to severe complications.Case descriptionWe present a case of a 61-year-old male with a history of lung cancer who presented with intestinal obstruction. The initial diagnosis of poorly differentiated adenocarcinoma was confirmed by computed tomography (CT) and bronchoscopic biopsy. The patient underwent chemotherapy, after which he developed intestinal obstruction. Further imaging and histopathological analysis indicated GI metastasis. Despite treatment with both chemotherapy and immunotherapy, the patient experienced recurrent obstruction, necessitating surgical intervention. Postoperatively, he had another episode of perforation, which was addressed with an emergency laparotomy, revealing metastatic adenocarcinoma at the site of perforation.ConclusionsThis case highlights the complexities in diagnosing and treating GI metastases from lung cancer. It underscores the necessity for multimodal treatment strategies and underscores the urgent need for research focused on early detection methods to improve patient outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2024.1486371/fulllung cancergastrointestinal complicationsmetastasisintestinal obstructionimmunotherapy response |
| spellingShingle | Xinxin Xu Qian Zhou Qian Zhou Peng Chen Chengzhou Du Yonghua Huang Xiaoxin Gao Shumei Xu Jinling Wu Tianxiao He Hongtao Li Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations Frontiers in Oncology lung cancer gastrointestinal complications metastasis intestinal obstruction immunotherapy response |
| title | Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations |
| title_full | Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations |
| title_fullStr | Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations |
| title_full_unstemmed | Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations |
| title_short | Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations |
| title_sort | exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma a case report highlighting diagnostic dilemmas and therapeutic innovations |
| topic | lung cancer gastrointestinal complications metastasis intestinal obstruction immunotherapy response |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1486371/full |
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