The association of motor reserve and clinical progression in Parkinson’s disease
Objective: To explore the association of motor reserve (MR) and clinical progression in Parkinson’s disease. Methods: This longitudinal study using data from the Parkinson’s progression markers initiative. Patients with de novo PD who underwent dopamine transporter scans at baseline and finished at...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224001451 |
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| author | Xueqin Bai Shiwei Zhang Qiuyue Li Tao Guo Xiaojun Guan Andan Qian Shuangli Chen Ronghui Zhou Yitong Cheng Haoxin Chen Zhaoke Gou Chenglong Xie Zhen Wang Minming Zhang Xiangwu Zheng Meihao Wang |
| author_facet | Xueqin Bai Shiwei Zhang Qiuyue Li Tao Guo Xiaojun Guan Andan Qian Shuangli Chen Ronghui Zhou Yitong Cheng Haoxin Chen Zhaoke Gou Chenglong Xie Zhen Wang Minming Zhang Xiangwu Zheng Meihao Wang |
| author_sort | Xueqin Bai |
| collection | DOAJ |
| description | Objective: To explore the association of motor reserve (MR) and clinical progression in Parkinson’s disease. Methods: This longitudinal study using data from the Parkinson’s progression markers initiative. Patients with de novo PD who underwent dopamine transporter scans at baseline and finished at least five years clinical follow-up assessments (including motor, cognitive, and non-motor symptoms) were included. The individual MR of PD patients were estimated based on initial motor deficits and striatal dopamine depletion using a residual model. Linear mixed-effects models (LME) were performed to examine the associations of baseline MR and clinical progression. Results: A total of 303 de novo PD patients were included and the mean follow-up time was 8.95 years. Results of LME models revealed that the baseline MR was associated with motor, cognitive, and non-motor symptoms in PD patients. There was a significant interaction between MR and disease duration for longitudinal changes in motor (p < 0.001), cognitive (p = 0.028) and depression symptoms (p = 0.014). PD patients with lower MR had a more rapid progression to postural instability and cognitive impairment compared with those with higher MR (p = 0.002 and p = 0.001, respectively). Conclusions: The baseline MR of PD patients were associated with motor and non-motor symptoms and can predicted disease prognosis, suggesting that the initial MR in PD would be associated with the individual’s capacity to cope with neurodegenerative process as well as comprehensive prognosis. |
| format | Article |
| id | doaj-art-ab9c9b9c5ce441d284f5b6e9a077c94b |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-ab9c9b9c5ce441d284f5b6e9a077c94b2024-11-29T06:23:46ZengElsevierNeuroImage: Clinical2213-15822024-01-0144103704The association of motor reserve and clinical progression in Parkinson’s diseaseXueqin Bai0Shiwei Zhang1Qiuyue Li2Tao Guo3Xiaojun Guan4Andan Qian5Shuangli Chen6Ronghui Zhou7Yitong Cheng8Haoxin Chen9Zhaoke Gou10Chenglong Xie11Zhen Wang12Minming Zhang13Xiangwu Zheng14Meihao Wang15Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, China; Corresponding author at: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, China.Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, China; Corresponding author at: Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, 325000 Wenzhou, China.The First Affiliated Hospital of Wenzhou Medical University and Key Laboratory of Intelligent Medical Imaging of Wenzhou, Wenzhou, China; Corresponding author at: The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, 325000 Wenzhou, China.Objective: To explore the association of motor reserve (MR) and clinical progression in Parkinson’s disease. Methods: This longitudinal study using data from the Parkinson’s progression markers initiative. Patients with de novo PD who underwent dopamine transporter scans at baseline and finished at least five years clinical follow-up assessments (including motor, cognitive, and non-motor symptoms) were included. The individual MR of PD patients were estimated based on initial motor deficits and striatal dopamine depletion using a residual model. Linear mixed-effects models (LME) were performed to examine the associations of baseline MR and clinical progression. Results: A total of 303 de novo PD patients were included and the mean follow-up time was 8.95 years. Results of LME models revealed that the baseline MR was associated with motor, cognitive, and non-motor symptoms in PD patients. There was a significant interaction between MR and disease duration for longitudinal changes in motor (p < 0.001), cognitive (p = 0.028) and depression symptoms (p = 0.014). PD patients with lower MR had a more rapid progression to postural instability and cognitive impairment compared with those with higher MR (p = 0.002 and p = 0.001, respectively). Conclusions: The baseline MR of PD patients were associated with motor and non-motor symptoms and can predicted disease prognosis, suggesting that the initial MR in PD would be associated with the individual’s capacity to cope with neurodegenerative process as well as comprehensive prognosis.http://www.sciencedirect.com/science/article/pii/S2213158224001451Parkinson’s diseaseMotor reserveClinical progressionCognition |
| spellingShingle | Xueqin Bai Shiwei Zhang Qiuyue Li Tao Guo Xiaojun Guan Andan Qian Shuangli Chen Ronghui Zhou Yitong Cheng Haoxin Chen Zhaoke Gou Chenglong Xie Zhen Wang Minming Zhang Xiangwu Zheng Meihao Wang The association of motor reserve and clinical progression in Parkinson’s disease NeuroImage: Clinical Parkinson’s disease Motor reserve Clinical progression Cognition |
| title | The association of motor reserve and clinical progression in Parkinson’s disease |
| title_full | The association of motor reserve and clinical progression in Parkinson’s disease |
| title_fullStr | The association of motor reserve and clinical progression in Parkinson’s disease |
| title_full_unstemmed | The association of motor reserve and clinical progression in Parkinson’s disease |
| title_short | The association of motor reserve and clinical progression in Parkinson’s disease |
| title_sort | association of motor reserve and clinical progression in parkinson s disease |
| topic | Parkinson’s disease Motor reserve Clinical progression Cognition |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224001451 |
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