Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier

Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier

Head and neck squamous cell carcinoma (HNSCC) remains a challenge due to limited prognostic biomarkers and therapeutic options. The tumor microenvironment (TME), particularly the desmoplastic reaction (DR) characterized by stromal fibrosis, plays a crucial role in cancer progression and resistance t...

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Bibliographic Details
Main Authors:	Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-02-01
Series:	Therapeutic Advances in Medical Oncology
Online Access:	https://doi.org/10.1177/17588359251317144
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