Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect
<i>Aconitum</i> stands out among the Ranunculaceae family for its notable use as an ornamental and medicinal plant. Diterpenoid alkaloids (DAs), the characteristic compounds of <i>Aconitum</i>, have been found to have effective analgesic and anti-inflammatory effects. Despite...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841549091281043456 |
|---|---|
| author | Ting Wang Cai Rangji Wenbin Liu Jing Ma Ruichen Zhou Liang Leng Yi Zhang |
| author_facet | Ting Wang Cai Rangji Wenbin Liu Jing Ma Ruichen Zhou Liang Leng Yi Zhang |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | <i>Aconitum</i> stands out among the Ranunculaceae family for its notable use as an ornamental and medicinal plant. Diterpenoid alkaloids (DAs), the characteristic compounds of <i>Aconitum</i>, have been found to have effective analgesic and anti-inflammatory effects. Despite their medicinal potential, the toxicity of most DAs restricts the direct use of <i>Aconitum</i> in traditional medicine, necessitating complex processing before use. The use of high-throughput omics allows for the investigation of <i>Aconitum</i> plant genetics, gene regulation, metabolic pathways, and growth and development. We have collected comprehensive information on the omics studies of <i>Aconitum</i> medicinal plants, encompassing genomics, transcriptomics, metabolomics, proteomics, and microbiomics, from internationally recognized electronic scientific databases such as Web of Science, PubMed, and CNKI. In light of this, we identified research gaps and proposed potential areas and key objectives for <i>Aconitum</i> omics research, aiming to establish a framework for quality improvement, molecular breeding, and a deeper understanding of specialized metabolite production in <i>Aconitum</i> plants. |
| format | Article |
| id | doaj-art-ab889d6fc65445d7811720290b996476 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-ab889d6fc65445d7811720290b9964762025-01-10T13:18:56ZengMDPI AGMolecules1420-30492024-12-0130111810.3390/molecules30010118Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and ProspectTing Wang0Cai Rangji1Wenbin Liu2Jing Ma3Ruichen Zhou4Liang Leng5Yi Zhang6State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China<i>Aconitum</i> stands out among the Ranunculaceae family for its notable use as an ornamental and medicinal plant. Diterpenoid alkaloids (DAs), the characteristic compounds of <i>Aconitum</i>, have been found to have effective analgesic and anti-inflammatory effects. Despite their medicinal potential, the toxicity of most DAs restricts the direct use of <i>Aconitum</i> in traditional medicine, necessitating complex processing before use. The use of high-throughput omics allows for the investigation of <i>Aconitum</i> plant genetics, gene regulation, metabolic pathways, and growth and development. We have collected comprehensive information on the omics studies of <i>Aconitum</i> medicinal plants, encompassing genomics, transcriptomics, metabolomics, proteomics, and microbiomics, from internationally recognized electronic scientific databases such as Web of Science, PubMed, and CNKI. In light of this, we identified research gaps and proposed potential areas and key objectives for <i>Aconitum</i> omics research, aiming to establish a framework for quality improvement, molecular breeding, and a deeper understanding of specialized metabolite production in <i>Aconitum</i> plants.https://www.mdpi.com/1420-3049/30/1/118<i>Aconitum</i>genomicstranscriptomicsmetabolomicsproteomicsmicrobiomics |
| spellingShingle | Ting Wang Cai Rangji Wenbin Liu Jing Ma Ruichen Zhou Liang Leng Yi Zhang Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect Molecules <i>Aconitum</i> genomics transcriptomics metabolomics proteomics microbiomics |
| title | Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect |
| title_full | Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect |
| title_fullStr | Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect |
| title_full_unstemmed | Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect |
| title_short | Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect |
| title_sort | multi omics on traditional medicinal plant of the genus i aconitum i current progress and prospect |
| topic | <i>Aconitum</i> genomics transcriptomics metabolomics proteomics microbiomics |
| url | https://www.mdpi.com/1420-3049/30/1/118 |
| work_keys_str_mv | AT tingwang multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT cairangji multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT wenbinliu multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT jingma multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT ruichenzhou multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT liangleng multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect AT yizhang multiomicsontraditionalmedicinalplantofthegenusiaconitumicurrentprogressandprospect |