Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial
Background: Periodontitis is a chronic inflammatory disease that damages the supporting structures of the teeth, primarily caused by dental plaque containing Gram-negative bacteria. These bacteria trigger an inflammatory host response leading to tissue destruction. Materials and Methods: A total of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_902_24 |
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| author | Supriya Shirodkar Amit Vasani Tanu Sahney Meet Modi Salini Pattnaik P. Ravi Tejeshwar Reddy |
| author_facet | Supriya Shirodkar Amit Vasani Tanu Sahney Meet Modi Salini Pattnaik P. Ravi Tejeshwar Reddy |
| author_sort | Supriya Shirodkar |
| collection | DOAJ |
| description | Background:
Periodontitis is a chronic inflammatory disease that damages the supporting structures of the teeth, primarily caused by dental plaque containing Gram-negative bacteria. These bacteria trigger an inflammatory host response leading to tissue destruction.
Materials and Methods:
A total of 84 patients with moderate to severe chronic periodontitis were randomly assigned to either a test group receiving 500 mg of hesperidin daily or a control group receiving a placebo both alongside scaling and root planing (SRP). Clinical parameters including the gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), and clinical attachment level (CAL) were evaluated at baseline, 3 weeks, and 6 weeks. Serum C-reactive protein (CRP) levels were measured at baseline and 3 weeks to assess systemic inflammation.
Results:
Of the 84 patients, 80 completed the study, with 60 males and 20 females. The test group showed significant reduction in serum CRP levels from baseline to 3 weeks (mean difference: 1.6300, P < 0.001), while the control group also showed a significant decrease (mean difference: -1.2730, P = 0.001). However, no statistically significant differences were found in clinical parameters (GI, SBI, PD, CAL) between the test and control groups at any time point. Intragroup analysis showed significant improvements in these parameters over time within both groups, indicating the effectiveness of SRP in managing clinical symptoms of periodontitis.
Conclusion:
Hesperidin significantly reduced serum CRP levels, indicating an anti-inflammatory effect, but did not result in significant improvements in clinical parameters compared to placebo. |
| format | Article |
| id | doaj-art-ab40f98fe553422db47b9280101a9dc8 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-ab40f98fe553422db47b9280101a9dc82025-01-13T09:49:52ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3421S342310.4103/jpbs.jpbs_902_24Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical TrialSupriya ShirodkarAmit VasaniTanu SahneyMeet ModiSalini PattnaikP. Ravi Tejeshwar ReddyBackground: Periodontitis is a chronic inflammatory disease that damages the supporting structures of the teeth, primarily caused by dental plaque containing Gram-negative bacteria. These bacteria trigger an inflammatory host response leading to tissue destruction. Materials and Methods: A total of 84 patients with moderate to severe chronic periodontitis were randomly assigned to either a test group receiving 500 mg of hesperidin daily or a control group receiving a placebo both alongside scaling and root planing (SRP). Clinical parameters including the gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), and clinical attachment level (CAL) were evaluated at baseline, 3 weeks, and 6 weeks. Serum C-reactive protein (CRP) levels were measured at baseline and 3 weeks to assess systemic inflammation. Results: Of the 84 patients, 80 completed the study, with 60 males and 20 females. The test group showed significant reduction in serum CRP levels from baseline to 3 weeks (mean difference: 1.6300, P < 0.001), while the control group also showed a significant decrease (mean difference: -1.2730, P = 0.001). However, no statistically significant differences were found in clinical parameters (GI, SBI, PD, CAL) between the test and control groups at any time point. Intragroup analysis showed significant improvements in these parameters over time within both groups, indicating the effectiveness of SRP in managing clinical symptoms of periodontitis. Conclusion: Hesperidin significantly reduced serum CRP levels, indicating an anti-inflammatory effect, but did not result in significant improvements in clinical parameters compared to placebo.https://journals.lww.com/10.4103/jpbs.jpbs_902_24anti-inflammatorychronic periodontitisc-reactive proteinhesperidinhost modulatory therapyscalingand root planing |
| spellingShingle | Supriya Shirodkar Amit Vasani Tanu Sahney Meet Modi Salini Pattnaik P. Ravi Tejeshwar Reddy Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial Journal of Pharmacy and Bioallied Sciences anti-inflammatory chronic periodontitis c-reactive protein hesperidin host modulatory therapy scaling and root planing |
| title | Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial |
| title_full | Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial |
| title_fullStr | Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial |
| title_full_unstemmed | Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial |
| title_short | Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial |
| title_sort | effect of hesperidin as an adjunct to scaling and root planing on clinical parameters and serum c reactive protein level in chronic periodontitis a randomized triple blind placebo controlled clinical trial |
| topic | anti-inflammatory chronic periodontitis c-reactive protein hesperidin host modulatory therapy scaling and root planing |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_902_24 |
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