Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis
Introduction: Hepatitis B and C are viral infections causing chronic liver inflammation and, when left untreated, lead to cirrhosis and a risk for hepatocellular carcinoma, the most common type of primary liver cancer with high mortality. The hepatitis B virus-hepatitis C virus (HBV-HCV) coinfection...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Global Infectious Diseases |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jgid.jgid_211_23 |
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| _version_ | 1841556591997878272 |
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| author | Abdullah A. Awadh Abdulrahman A. Alharthi Basil A. Alghamdi Seraj T. Alghamdi Mohammed K. Baqays Ibrahim S. Binrabaa Israa A. Malli |
| author_facet | Abdullah A. Awadh Abdulrahman A. Alharthi Basil A. Alghamdi Seraj T. Alghamdi Mohammed K. Baqays Ibrahim S. Binrabaa Israa A. Malli |
| author_sort | Abdullah A. Awadh |
| collection | DOAJ |
| description | Introduction:
Hepatitis B and C are viral infections causing chronic liver inflammation and, when left untreated, lead to cirrhosis and a risk for hepatocellular carcinoma, the most common type of primary liver cancer with high mortality. The hepatitis B virus-hepatitis C virus (HBV-HCV) coinfection leads to a faster progression to advanced liver diseases and higher hepatocellular carcinoma (HCC) risk than monoinfection. Unlike the relative risk for HCC due to either HBV or HCV, no recent analysis of the risk for HBV-HCV coinfection exists.
Methods:
Based on PRISMA recommendations and guidelines, we developed a search strategy by combining the keywords (“hepatitis B”) and (“hepatitis C”) and (“hepatocellular carcinoma” or “liver cancer”). First, we performed a title and abstract screening and, later, a full-text screening. We extracted the demographic characteristics, such as gender, age, study design, sample size, country, and biomarkers of hepatitis B surface antigen (HBsAg), HBV DNA, HBeAg, anti-HCV, and HCV RNA. The data were assessed for quality, and the Review Manager software was used for the meta-analysis.
Results:
We included 63 studies. The pooled analysis showed that the risk of HCC was significantly higher in the case-cohort who were positive for HBsAg (odds ratio [OR] = 9.70 [3.75, 25.12], P = 0.0001), HBV DNA or HBeAg (OR = 22.77 [10.00, 51.88], P = 0.0001), HBV and HCV coinfection (OR = 46.07 [26.33, 80.60], P = 0.0001) than the control cohort.
Conclusion:
Chronic HBV and HCV infections are major risk factors for HCC, and their coinfection was significantly associated with an increased risk of HCC than monoinfection. |
| format | Article |
| id | doaj-art-ab2c81a70a3748b6a7918469bc097f05 |
| institution | Kabale University |
| issn | 0974-777X 0974-8245 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Global Infectious Diseases |
| spelling | doaj-art-ab2c81a70a3748b6a7918469bc097f052025-01-07T07:10:17ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X0974-82452024-12-0116412713410.4103/jgid.jgid_211_23Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysisAbdullah A. AwadhAbdulrahman A. AlharthiBasil A. AlghamdiSeraj T. AlghamdiMohammed K. BaqaysIbrahim S. BinrabaaIsraa A. MalliIntroduction: Hepatitis B and C are viral infections causing chronic liver inflammation and, when left untreated, lead to cirrhosis and a risk for hepatocellular carcinoma, the most common type of primary liver cancer with high mortality. The hepatitis B virus-hepatitis C virus (HBV-HCV) coinfection leads to a faster progression to advanced liver diseases and higher hepatocellular carcinoma (HCC) risk than monoinfection. Unlike the relative risk for HCC due to either HBV or HCV, no recent analysis of the risk for HBV-HCV coinfection exists. Methods: Based on PRISMA recommendations and guidelines, we developed a search strategy by combining the keywords (“hepatitis B”) and (“hepatitis C”) and (“hepatocellular carcinoma” or “liver cancer”). First, we performed a title and abstract screening and, later, a full-text screening. We extracted the demographic characteristics, such as gender, age, study design, sample size, country, and biomarkers of hepatitis B surface antigen (HBsAg), HBV DNA, HBeAg, anti-HCV, and HCV RNA. The data were assessed for quality, and the Review Manager software was used for the meta-analysis. Results: We included 63 studies. The pooled analysis showed that the risk of HCC was significantly higher in the case-cohort who were positive for HBsAg (odds ratio [OR] = 9.70 [3.75, 25.12], P = 0.0001), HBV DNA or HBeAg (OR = 22.77 [10.00, 51.88], P = 0.0001), HBV and HCV coinfection (OR = 46.07 [26.33, 80.60], P = 0.0001) than the control cohort. Conclusion: Chronic HBV and HCV infections are major risk factors for HCC, and their coinfection was significantly associated with an increased risk of HCC than monoinfection.https://journals.lww.com/10.4103/jgid.jgid_211_23hepatitishepatitis bhepatitis chepatocellular carcinomalivermeta-analysis |
| spellingShingle | Abdullah A. Awadh Abdulrahman A. Alharthi Basil A. Alghamdi Seraj T. Alghamdi Mohammed K. Baqays Ibrahim S. Binrabaa Israa A. Malli Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis Journal of Global Infectious Diseases hepatitis hepatitis b hepatitis c hepatocellular carcinoma liver meta-analysis |
| title | Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis |
| title_full | Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis |
| title_fullStr | Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis |
| title_full_unstemmed | Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis |
| title_short | Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis |
| title_sort | coinfection of hepatitis b and c viruses and risk of hepatocellular carcinoma systematic review and meta analysis |
| topic | hepatitis hepatitis b hepatitis c hepatocellular carcinoma liver meta-analysis |
| url | https://journals.lww.com/10.4103/jgid.jgid_211_23 |
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